An Update on Recent Advances of Photodynamic Therapy for Primary Cutaneous Lymphomas

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 May 27

PMID 37242570

Authors

Wei-Ting Liu

Han-Tang Wang

Yi-Hsuan Yeh

Tak-Wah Wong

Affiliations

Soon will be listed here.

Abstract

Primary cutaneous lymphomas are rare non-Hodgkin lymphomas consisting of heterogeneous disease entities. Photodynamic therapy (PDT) utilizing photosensitizers irradiated with a specific wavelength of light in the presence of oxygen exerts promising anti-tumor effects on non-melanoma skin cancer, yet its application in primary cutaneous lymphomas remains less recognized. Despite many in vitro data showing PDT could effectively kill lymphoma cells, clinical evidence of PDT against primary cutaneous lymphomas is limited. Recently, a phase 3 "FLASH" randomized clinical trial demonstrated the efficacy of topical hypericin PDT for early-stage cutaneous T-cell lymphoma. An update on recent advances of photodynamic therapy in primary cutaneous lymphomas is provided.

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