Visualization of Phototherapy Evolution by Optical Imaging

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 May 27

PMID 37241733

Authors

ZhiHeng Li

Zheng Li

Jie Wang

Affiliations

Soon will be listed here.

Abstract

Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a non-invasive and effective approach used for cancer treatment, in which phototherapeutic agents are irradiated with an appropriate light source to produce cytotoxic reactive oxygen species (ROS) or heat to ablate cancer cells. Unfortunately, traditional phototherapy lacks a facile imaging method to monitor the therapeutic process and efficiency in real time, usually leading to severe side effects due to high levels of ROS and hyperthermia. To realize precise cancer treatment methods, it is highly desired to develop phototherapeutic agents possessing an imaging ability to evaluate the therapeutic process and efficacy in real time during cancer phototherapy. Recently, a series of self-reporting phototherapeutic agents were reported to monitor PDT and PTT processes by combining optical imaging technologies with phototherapy. Due to the real-time feedback provided by optical imaging technology, therapeutic responses or dynamic changes in the tumor microenvironment could be evaluated in a timely manner, thereby achieving personalized precision treatment and minimizing toxic side effects. In this review, we focus on the advances in the development of self-reporting phototherapeutic agents for a cancer phototherapy evaluation based on optical imaging technology to realize precision cancer treatments. Additionally, we propose the current challenges and future directions of self-reporting agents for precision medicine.

Citing Articles

Bimodal persistent luminescence for autofluorescence-free ratiometric biosensing.

Dai W, Qi B, Li Z, Wang J Anal Bioanal Chem. 2023; 415(27):6723-6731.

PMID: 37733257 DOI: 10.1007/s00216-023-04949-4.

References

Karges J . Clinical Development of Metal Complexes as Photosensitizers for Photodynamic Therapy of Cancer. Angew Chem Int Ed Engl. 2021; 61(5):e202112236. DOI: 10.1002/anie.202112236. View

Sun X, Sun J, Dong B, Huang G, Zhang L, Zhou W . Noninvasive temperature monitoring for dual-modal tumor therapy based on lanthanide-doped up-conversion nanocomposites. Biomaterials. 2019; 201:42-52. DOI: 10.1016/j.biomaterials.2019.02.014. View

Liu X, Zhan W, Gao G, Jiang Q, Zhang X, Zhang H . Apoptosis-Amplified Assembly of Porphyrin Nanofiber Enhances Photodynamic Therapy of Oral Tumor. J Am Chem Soc. 2023; 145(14):7918-7930. DOI: 10.1021/jacs.2c13189. View

Yang Z, Wen J, Wang Q, Li Y, Zhao Y, Tian Y . Sensitive, Real-Time, and In-Vivo Oxygen Monitoring for Photodynamic Therapy by Multifunctional Mesoporous Nanosensors. ACS Appl Mater Interfaces. 2018; 11(1):187-194. DOI: 10.1021/acsami.8b16801. View

Siegel R, Miller K, Wagle N, Jemal A . Cancer statistics, 2023. CA Cancer J Clin. 2023; 73(1):17-48. DOI: 10.3322/caac.21763. View

Zubair R, Hamzavi I . Phototherapy for Vitiligo. Dermatol Clin. 2019; 38(1):55-62. DOI: 10.1016/j.det.2019.08.005. View

Liao S, Wang Y, Li Z, Zhang Y, Yin X, Huan S . A novel afterglow nanoreporter for monitoring cancer therapy. Theranostics. 2022; 12(16):6883-6897. PMC: 9576607. DOI: 10.7150/thno.77457. View

He M, Wang Y, Li D, Zhang M, Wang T, Zhi F . Recent applications of phase-change materials in tumor therapy and theranostics. Biomater Adv. 2023; 147:213309. DOI: 10.1016/j.bioadv.2023.213309. View

Hak A, Shinde V, Rengan A . A review of advanced nanoformulations in phototherapy for cancer therapeutics. Photodiagnosis Photodyn Ther. 2021; 33:102205. DOI: 10.1016/j.pdpdt.2021.102205. View

10.

Li J, Zhang W, Ji W, Wang J, Wang N, Wu W . Near infrared photothermal conversion materials: mechanism, preparation, and photothermal cancer therapy applications. J Mater Chem B. 2021; 9(38):7909-7926. DOI: 10.1039/d1tb01310f. View

11.

Kemeny L, Varga E, Novak Z . Advances in phototherapy for psoriasis and atopic dermatitis. Expert Rev Clin Immunol. 2019; 15(11):1205-1214. DOI: 10.1080/1744666X.2020.1672537. View

12.

Wang J, Zhu X, Zhang J, Wang H, Liu G, Bu Y . AIE-Based Theranostic Agent: In Situ Tracking Mitophagy Prior to Late Apoptosis To Guide the Photodynamic Therapy. ACS Appl Mater Interfaces. 2019; 12(2):1988-1996. DOI: 10.1021/acsami.9b15577. View

13.

Eisenhauer E, Therasse P, Bogaerts J, Schwartz L, Sargent D, Ford R . New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2008; 45(2):228-47. DOI: 10.1016/j.ejca.2008.10.026. View

14.

Kang Y, Zheng B, Li C, Zhang Z, Tang H, Wu Q . Real-Time Monitoring of Temperature Variations around a Gold Nanobipyramid Targeted Cancer Cell under Photothermal Heating by Actively Manipulating an Optically Trapped Luminescent Upconversion Microparticle. Anal Chem. 2019; 92(1):1292-1300. DOI: 10.1021/acs.analchem.9b04470. View

15.

Jeffrey Maisels M, McDonagh A . Phototherapy for neonatal jaundice. N Engl J Med. 2008; 358(9):920-8. DOI: 10.1056/NEJMct0708376. View

16.

Sun J, Xing F, Braun J, Traub F, Rommens P, Xiang Z . Progress of Phototherapy Applications in the Treatment of Bone Cancer. Int J Mol Sci. 2021; 22(21). PMC: 8584114. DOI: 10.3390/ijms222111354. View

17.

Wang H, Wang Z, Li Y, Xu T, Zhang Q, Yang M . A Novel Theranostic Nanoprobe for In Vivo Singlet Oxygen Detection and Real-Time Dose-Effect Relationship Monitoring in Photodynamic Therapy. Small. 2019; 15(39):e1902185. DOI: 10.1002/smll.201902185. View

18.

Aires-Fernandes M, Botelho Costa R, do Amaral S, Mussagy C, Santos-Ebinuma V, Primo F . Development of Biotechnological Photosensitizers for Photodynamic Therapy: Cancer Research and Treatment-From Benchtop to Clinical Practice. Molecules. 2022; 27(20). PMC: 9609562. DOI: 10.3390/molecules27206848. View

19.

Yang M, Zhang J, Shabat D, Fan J, Peng X . Near-Infrared Chemiluminescent Probe for Real-Time Monitoring Singlet Oxygen in Cells and Mice Model. ACS Sens. 2020; 5(10):3158-3164. DOI: 10.1021/acssensors.0c01291. View

20.

Li J, Pu K . Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation. Chem Soc Rev. 2018; 48(1):38-71. DOI: 10.1039/c8cs00001h. View