Highly Selective Targeting of Pancreatic Cancer in the Liver with a Near-Infrared Anti-MUC5AC Probe in a PDOX Mouse Model: A Proof-of-Concept Study

Overview

Journal J Pers Med

Date 2023 May 27

PMID 37241027

Authors

Michael A Turner

Kristin E Cox

Nicholas Neel

Siamak Amirfakhri

Hiroto Nishino

Bryan M Clary

Mojgan Hosseini

Gopalakrishnan Natarajan

Kavita Mallya

Aaron M Mohs

Robert M Hoffman

Surinder K Batra

Michael Bouvet

Affiliations

Soon will be listed here.

Abstract

Accurately identifying metastatic disease is critical to directing the appropriate treatment in pancreatic cancer. Mucin 5AC is overexpressed in pancreatic cancer but absent in normal pancreas tissue. The present proof-of-concept study demonstrates the efficacy of an anti-mucin 5AC antibody conjugated to an IR800 dye (MUC5AC-IR800) to preferentially label a liver metastasis of pancreatic cancer () in a unique patient-derived orthotopic xenograft (PDOX) model. In orthotopic models, the mean tumor to background ratio was 1.787 (SD ± 0.336), and immunohistochemistry confirmed the expression of MUC5AC within tumor cells. MUC5AC-IR800 provides distinct visualization of pancreatic cancer liver metastasis in a PDOX mouse model, demonstrating its potential utility in staging laparoscopy and fluorescence-guided surgery.

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