Lavandula Species, Their Bioactive Phytochemicals, and Their Biosynthetic Regulation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 May 27

PMID 37240177

Authors

Miroslav Haban

Joanna Korczyk-Szabo

Simona certekova

Katarina Razna

Affiliations

Soon will be listed here.

Abstract

Lavandula species are one of the most useful aromatic and medicinal plants and have great economic potential. The phytopharmaceutical contribution of the secondary metabolites of the species is unquestionable. Most recent studies have been focusing on the elucidation of the genetic background of secondary metabolite production in lavender species. Therefore, knowledge of not only genetic but especially epigenetic mechanisms for the regulation of secondary metabolites is necessary for the modification of those biosynthesis processes and the understanding of genotypic differences in the content and compositional variability of these products. The review discusses the genetic diversity of Lavandula species in relation to the geographic area, occurrence, and morphogenetic factors. The role of microRNAs in secondary-metabolites biosynthesis is described.

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References

Maurya S, Chandra M, Yadav R, Narnoliya L, Sangwan R, Bansal S . Interspecies comparative features of trichomes in Ocimum reveal insights for biosynthesis of specialized essential oil metabolites. Protoplasma. 2019; 256(4):893-907. DOI: 10.1007/s00709-018-01338-y. View

Cavanagh H, Wilkinson J . Biological activities of lavender essential oil. Phytother Res. 2002; 16(4):301-8. DOI: 10.1002/ptr.1103. View

Pani A, Mahapatra R . Computational identification of microRNAs and their targets in Catharanthus roseus expressed sequence tags. Genom Data. 2015; 1:2-6. PMC: 4608865. DOI: 10.1016/j.gdata.2013.06.001. View

Sun M, Shi M, Wang Y, Huang Q, Yuan T, Wang Q . The biosynthesis of phenolic acids is positively regulated by the JA-responsive transcription factor ERF115 in Salvia miltiorrhiza. J Exp Bot. 2018; 70(1):243-254. DOI: 10.1093/jxb/ery349. View

Demissie Z, Erland L, Rheault M, Mahmoud S . The biosynthetic origin of irregular monoterpenes in Lavandula: isolation and biochemical characterization of a novel cis-prenyl diphosphate synthase gene, lavandulyl diphosphate synthase. J Biol Chem. 2013; 288(9):6333-41. PMC: 3585068. DOI: 10.1074/jbc.M112.431171. View

Lange B, Wildung M, Stauber E, Sanchez C, Pouchnik D, Croteau R . Probing essential oil biosynthesis and secretion by functional evaluation of expressed sequence tags from mint glandular trichomes. Proc Natl Acad Sci U S A. 2000; 97(6):2934-9. PMC: 16033. DOI: 10.1073/pnas.97.6.2934. View

Panchy N, Lehti-Shiu M, Shiu S . Evolution of Gene Duplication in Plants. Plant Physiol. 2016; 171(4):2294-316. PMC: 4972278. DOI: 10.1104/pp.16.00523. View

Samuelson R, Lobl M, Higgins S, Clarey D, Wysong A . The Effects of Lavender Essential Oil on Wound Healing: A Review of the Current Evidence. J Altern Complement Med. 2020; 26(8):680-690. DOI: 10.1089/acm.2019.0286. View

Nutzmann H, Huang A, Osbourn A . Plant metabolic clusters - from genetics to genomics. New Phytol. 2016; 211(3):771-89. PMC: 5449196. DOI: 10.1111/nph.13981. View

10.

Demissie Z, Sarker L, Mahmoud S . Cloning and functional characterization of β-phellandrene synthase from Lavandula angustifolia. Planta. 2010; 233(4):685-96. DOI: 10.1007/s00425-010-1332-5. View

11.

Li J, Wang Y, Dong Y, Zhang W, Wang D, Bai H . The chromosome-based lavender genome provides new insights into Lamiaceae evolution and terpenoid biosynthesis. Hortic Res. 2021; 8(1):53. PMC: 7917091. DOI: 10.1038/s41438-021-00490-6. View

12.

Vasileva I, Denkova R, Chochkov R, Teneva D, Denkova Z, Dessev T . Effect of lavender (Lavandula angustifolia) and melissa (Melissa Officinalis) waste on quality and shelf life of bread. Food Chem. 2018; 253:13-21. DOI: 10.1016/j.foodchem.2018.01.131. View

13.

Jamroz E, Juszczak L, Kucharek M . Investigation of the physical properties, antioxidant and antimicrobial activity of ternary potato starch-furcellaran-gelatin films incorporated with lavender essential oil. Int J Biol Macromol. 2018; 114:1094-1101. DOI: 10.1016/j.ijbiomac.2018.04.014. View

14.

Christianson D . Unearthing the roots of the terpenome. Curr Opin Chem Biol. 2008; 12(2):141-50. PMC: 2430190. DOI: 10.1016/j.cbpa.2007.12.008. View

15.

Adal A, Sarker L, Lemke A, Mahmoud S . Isolation and functional characterization of a methyl jasmonate-responsive 3-carene synthase from Lavandula x intermedia. Plant Mol Biol. 2017; 93(6):641-657. DOI: 10.1007/s11103-017-0588-6. View

16.

Sarker L, Demissie Z, Mahmoud S . Cloning of a sesquiterpene synthase from Lavandula x intermedia glandular trichomes. Planta. 2013; 238(5):983-9. DOI: 10.1007/s00425-013-1937-6. View

17.

Rathore S, Kumar R . Essential Oil Content and Compositional Variability of Species Cultivated in the Mid Hill Conditions of the Western Himalaya. Molecules. 2022; 27(11). PMC: 9182314. DOI: 10.3390/molecules27113391. View

18.

Pokajewicz K, Bialon M, Svydenko L, Fedin R, Hudz N . Chemical Composition of the Essential Oil of the New Cultivars of Mill. Bred in Ukraine. Molecules. 2021; 26(18). PMC: 8465323. DOI: 10.3390/molecules26185681. View

19.

Despinasse Y, Fiorucci S, Antonczak S, Moja S, Bony A, Nicole F . Bornyl-diphosphate synthase from Lavandula angustifolia: A major monoterpene synthase involved in essential oil quality. Phytochemistry. 2017; 137:24-33. DOI: 10.1016/j.phytochem.2017.01.015. View

20.

Landmann C, Hucherig S, Fink B, Hoffmann T, Dittlein D, Coiner H . Substrate promiscuity of a rosmarinic acid synthase from lavender (Lavandula angustifolia L.). Planta. 2011; 234(2):305-20. DOI: 10.1007/s00425-011-1400-5. View