Identification of Metabolic Factors and Inflammatory Markers Predictive of Outcome After Total Knee Arthroplasty in Patients with Knee Osteoarthritis: A Systematic Review

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2023 May 27

PMID 37239524

Authors

Lotte Meert

Michel Gcam Mertens

Mira Meeus

Sophie Vervullens

Isabel Baert

David Beckwee

Peter Verdonk

Rob J E M Smeets

Affiliations

Soon will be listed here.

Abstract

Objective: To identify metabolic factors and inflammatory markers that are predictive of postoperative total knee arthroplasty (TKA) outcome.

Method: A systematic search of the existing literature was performed using the electronic databases PubMed, Web of Science and Embase until the 1 of August 2022. Studies that evaluated the influence of metabolic or inflammatory markers (I) on postsurgical outcome (O) in end-stage knee osteoarthritis patients awaiting primary TKA (P) were included in this review.

Results: In total, 49 studies were included. Risk of bias of the included studies was low for one study, moderate for 10 studies and high for the remaining 38 studies. Conflicting evidence was found for the influence of body mass index, diabetes, cytokine levels and dyslipidaemia on pain, function, satisfaction and quality of life at more than six months after TKA.

Conclusions: Several limitations such as not taking into account known confounding factors, the use of many different outcome measures and a widely varying follow-up period made it challenging to draw firm conclusions and clinical implications. Therefore large-scaled longitudinal studies assessing the predictive value of metabolic and inflammatory factors pre-surgery in addition to the already evidenced risk factors with follow-up of one year after TKA are warranted.

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