Meropenem MICs at Standard and High Inocula and Mutant Prevention Concentration Inter-Relations: Comparative Study with Non-Carbapenemase-Producing and OXA-48-, KPC- and NDM-Producing

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2023 May 27

PMID 37237775

Authors

Maria V Golikova

Elena N Strukova

Kamilla N Alieva

Vladimir A Ageevets

Alisa A Avdeeva

Ofeliia S Sulian

Stephen H Zinner

Affiliations

Soon will be listed here.

Abstract

The minimal inhibitory concentration (MIC) is conventionally used to define in vitro levels of susceptibility or resistance of a specific bacterial strain to an antibiotic and to predict its clinical efficacy. Along with MIC, other measures of bacteria resistance exist: the MIC determined at high bacterial inocula (MIC) that allow the estimation of the occurrence of inoculum effect (IE) and the mutant prevention concentration, MPC. Together, MIC, MIC and MPC represent the bacterial "resistance profile". In this paper, we provide a comprehensive analysis of such profiles of strains that differ by meropenem susceptibility, ability to produce carbapenemases and specific carbapenemase types. In addition, we have analyzed inter-relations between the MIC, MIC and MPC for each tested strain. Low IE probability was detected with carbapenemase-non-producing and high IE probability was detected with those that were carbapenemase-producing. MICs did not correlate with the MPCs; significant correlation was observed between the MICs and the MPCs, indicating that these bacteria/antibiotic characteristics display similar resistance properties of a given bacterial strain. To determine the possible resistance-related risk due to a given strain, we propose determining the MIC. This can more or less predict the MPC value of the particular strain.

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