Enzymatic Bioconjugation: A Perspective from the Pharmaceutical Industry

Overview

Journal JACS Au

Publisher American Chemical Society

Specialty Chemistry

Date 2023 May 26

PMID 37234110

Authors

Aaron Debon

Elina Siirola

Radka Snajdrova

Affiliations

Soon will be listed here.

Abstract

Enzymes have firmly established themselves as bespoke catalysts for small molecule transformations in the pharmaceutical industry, from early research and development stages to large-scale production. In principle, their exquisite selectivity and rate acceleration can also be leveraged for modifying macromolecules to form bioconjugates. However, available catalysts face stiff competition from other bioorthogonal chemistries. In this Perspective, we seek to illuminate applications of enzymatic bioconjugation in the face of an expanding palette of new drug modalities. With these applications, we wish to highlight some examples of current successes and pitfalls of using enzymes for bioconjugation along the pipeline and try to illustrate opportunities for further development.

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