Chitosan Hydrogel As Tissue Engineering Scaffolds for Vascular Regeneration Applications

Overview

Journal Gels

Date 2023 May 26

PMID 37232967

Authors

Qiulin Wang

Xiaoyu Wang

Yakai Feng

Affiliations

Soon will be listed here.

Abstract

Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds, mainly due to the advantages of their chemical and physical properties. This review focuses on the application of chitosan hydrogels in tissue engineering scaffolds for vascular regeneration. We have mainly introduced these following aspects: advantages and progress of chitosan hydrogels in vascular regeneration hydrogels and the modification of chitosan hydrogels to improve the application in vascular regeneration. Finally, this paper discusses the prospects of chitosan hydrogels for vascular regeneration.

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References

Kang M, Kim J, Im G . Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis. Acta Biomater. 2016; 39:65-78. DOI: 10.1016/j.actbio.2016.05.005. View

Hann S, Cui H, Chen G, Boehm M, Esworthy T, Zhang L . 3D printed biomimetic flexible blood vessels with iPS cell-laden hierarchical multilayers. Biomed Eng Adv. 2022; 4. PMC: 9794201. DOI: 10.1016/j.bea.2022.100065. View

Gao B, Zhang Q, Wang X, Wang M, Ren X, Guo J . A "self-accelerating endosomal escape" siRNA delivery nanosystem for significantly suppressing hyperplasia via blocking the ERK2 pathway. Biomater Sci. 2019; 7(8):3307-3319. DOI: 10.1039/c9bm00451c. View

Li Y, Li J, Shi Z, Wang Y, Song X, Wang L . Anticoagulant chitosan-kappa-carrageenan composite hydrogel sorbent for simultaneous endotoxin and bacteria cleansing in septic blood. Carbohydr Polym. 2020; 243:116470. DOI: 10.1016/j.carbpol.2020.116470. View

Li Q, Hao X, Wang H, Guo J, Ren X, Xia S . Multifunctional REDV-G-TAT-G-NLS-Cys peptide sequence conjugated gene carriers to enhance gene transfection efficiency in endothelial cells. Colloids Surf B Biointerfaces. 2019; 184:110510. DOI: 10.1016/j.colsurfb.2019.110510. View

Chen Y, Jia Z, Shafiq M, Xie X, Xiao X, Castro R . Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration. Colloids Surf B Biointerfaces. 2021; 201:111637. DOI: 10.1016/j.colsurfb.2021.111637. View

Ngo D, Kim S . Antioxidant effects of chitin, chitosan, and their derivatives. Adv Food Nutr Res. 2014; 73:15-31. DOI: 10.1016/B978-0-12-800268-1.00002-0. View

Thottappillil N, Nair P . Dual source co-electrospun tubular scaffold generated from gelatin-vinyl acetate and poly-ɛ-caprolactone for smooth muscle cell mediated blood vessel engineering. Mater Sci Eng C Mater Biol Appl. 2020; 114:111030. DOI: 10.1016/j.msec.2020.111030. View

Ways T, Lau W, Khutoryanskiy V . Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems. Polymers (Basel). 2019; 10(3). PMC: 6414903. DOI: 10.3390/polym10030267. View

10.

Zhou W, Feng Y, Yang J, Fan J, Lv J, Zhang L . Electrospun scaffolds of silk fibroin and poly(lactide-co-glycolide) for endothelial cell growth. J Mater Sci Mater Med. 2015; 26(1):5386. DOI: 10.1007/s10856-015-5386-6. View

11.

Zhao J, Bai L, Ren X, Guo J, Xia S, Zhang W . Co-immobilization of ACH antithrombotic peptide and CAG cell-adhesive peptide onto vascular grafts for improved hemocompatibility and endothelialization. Acta Biomater. 2019; 97:344-359. DOI: 10.1016/j.actbio.2019.07.057. View

12.

Wang B, Hua J, You R, Yan K, Ma L . Electrochemically deposition of catechol-chitosan hydrogel coating on coronary stent with robust copper ions immobilization capability and improved interfacial biological activity. Int J Biol Macromol. 2021; 181:435-443. DOI: 10.1016/j.ijbiomac.2021.03.158. View

13.

Lopresti F, Liga A, Capuana E, Gulfi D, Zanca C, Inguanta R . Effect of Polyhydroxyalkanoate (PHA) Concentration on Polymeric Scaffolds Based on Blends of Poly-L-Lactic Acid (PLLA) and PHA Prepared via Thermally Induced Phase Separation (TIPS). Polymers (Basel). 2022; 14(12). PMC: 9229920. DOI: 10.3390/polym14122494. View

14.

Baysan G, Colpankan Gunes O, Akokay P, Husemoglu R, Ertugruloglu P, Ziylan Albayrak A . Loofah-chitosan and poly (-3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) based hydrogel scaffolds for meniscus tissue engineering applications. Int J Biol Macromol. 2022; 221:1171-1183. DOI: 10.1016/j.ijbiomac.2022.09.031. View

15.

Mokhtari N, Kharazi A . Blood compatibility and cell response improvement of poly glycerol sebacate/poly lactic acid scaffold for vascular graft applications. J Biomed Mater Res A. 2021; 109(12):2673-2684. DOI: 10.1002/jbm.a.37259. View

16.

Miller R, Chan C, Rastogi A, Grant A, White C, Bette N . Combining electrospun nanofibers with cell-encapsulating hydrogel fibers for neural tissue engineering. J Biomater Sci Polym Ed. 2018; 29(13):1625-1642. PMC: 7446748. DOI: 10.1080/09205063.2018.1479084. View

17.

Qi R, Liu W, Wang D, Meng F, Wang H, Qi H . Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: and investigations. Drug Deliv. 2020; 28(1):54-62. PMC: 7751425. DOI: 10.1080/10717544.2020.1856220. View

18.

Wang T, Zhou Y, Xie W, Chen L, Zheng H, Fan L . Preparation and anticoagulant activity of N-succinyl chitosan sulfates. Int J Biol Macromol. 2012; 51(5):808-14. DOI: 10.1016/j.ijbiomac.2012.07.029. View

19.

Chien Y, Liao Y, Liu D, Lin H, Chen S, Chen H . Corneal repair by human corneal keratocyte-reprogrammed iPSCs and amphiphatic carboxymethyl-hexanoyl chitosan hydrogel. Biomaterials. 2012; 33(32):8003-16. DOI: 10.1016/j.biomaterials.2012.07.029. View

20.

Gao Y, Zhang X, Jin X . Preparation and Properties of Minocycline-Loaded Carboxymethyl Chitosan Gel/Alginate Nonwovens Composite Wound Dressings. Mar Drugs. 2019; 17(10). PMC: 6835814. DOI: 10.3390/md17100575. View