An International Investigation of Molar Incisor Hypomineralisation (iMIH) and Its Association with Dental Anomalies: Development of a Protocol

Overview

Journal Dent J (Basel)

Specialty Dentistry

Date 2023 May 26

PMID 37232768

Authors

Helen D Rodd

Hani Nazzal

Clarissa Calil Bonifacio

Choe Wei Ruth

Felicity Crombie

Osama El Shahawy

Morenike Oluwatoyin Folayan

Karla Gambetta-Tessini

Ashima Goyal

Noren Hasmun

Ahmad I Issa

Suhad Jundi

David J Manton

Srinivasan Narasimhan

Samah Omar

Susan Parekh

Bamidele O Popoola

Mihiri Silva

Greig Taylor

Yang Qiyue Naomi

Affiliations

Soon will be listed here.

Abstract

Background: Molar incisor hypomineralisation (MIH) is a common disorder of tooth development, which has recently been found to be associated with a higher prevalence of hypodontia. The aim of this international multicentre study is to determine the association between MIH and other developmental anomalies in different populations.

Methods: Investigators were trained and calibrated for the assessment of MIH and dental anomalies and ethical approvals obtained in each participating country. The study aimed to recruit 584 children with MIH and 584 children without MIH. Patients aged 7-16 years who attend specialist clinics will be invited to participate. Children will undergo a clinical examination to determine the presence and severity of MIH, using an established index. The presence of any other anomalies, affecting tooth number, morphology, or position, will be documented. Panoramic radiographs will be assessed for dental anomalies and the presence of third permanent molars. Statistical analysis, using a chi squared test and regression analysis, will be performed to determine any differences in dental anomaly prevalence between the MIH and non-MIH group and to determine any association between dental anomalies and patient characteristics.

Conclusion: This large-scale study has the potential to improve understanding about MIH with benefits for patient management.

Citing Articles

Molar Incisor Hypomineralization: Etiology, Correlation with Tooth Number Anomalies and Implications for Comprehensive Management Strategies in Children from Transylvania.

Contac L, Pop S, Voidazan S, Bica C Diagnostics (Basel). 2024; 14(21).

PMID: 39518339 PMC: 11545825. DOI: 10.3390/diagnostics14212370.

Association between molar incisor hypomineralisation and tooth agenesis: a cross-sectional study in Brazilian children and adolescents.

Fernandes E, Costa L, Santos P Eur Arch Paediatr Dent. 2024; 25(6):891-898.

PMID: 39417959 DOI: 10.1007/s40368-024-00948-w.

Potential Association of Molar-Incisor Hypomineralization (MIH) with Dental Agenesis and Infraoccluded Deciduous Molars: Is MIH Related to Dental Anomaly Pattern (DAP)? An Observational Cross-Sectional Study.

Marcianes M, Garcia-Camba P, Albaladejo A, Varela Morales M J Clin Med. 2024; 13(8).

PMID: 38673718 PMC: 11051123. DOI: 10.3390/jcm13082445.

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