Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease

Overview

Journal Nephron

Publisher Karger

Specialty Nephrology

Date 2023 May 26

PMID 37232009

Authors

Ibrahim Sandokji

Yunwen Xu

Michelle Denburg

Susan Furth

Alison G Abraham

Jason H Greenberg

Affiliations

Soon will be listed here.

Abstract

Background: Due to the complexity of chronic kidney disease (CKD) pathophysiology, biomarkers representing different mechanistic pathways have been targeted for the study and development of novel biomarkers. The discovery of clinically useful CKD biomarkers would allow for the identification of those children at the highest risk of kidney function decline for timely interventions and enrollment in clinical trials.

Summary: Glomerular filtration rate and proteinuria are traditional biomarkers to classify and prognosticate CKD progression in clinical practice but have several limitations. Over the recent decades, novel biomarkers have been identified from blood or urine with metabolomic screening studies, proteomic screening studies, and an improved knowledge of CKD pathophysiology. This review highlights promising biomarkers associated with the progression of CKD that could potentially serve as future prognostic markers in children with CKD.

Key Messages: Further studies are needed in children with CKD to validate putative biomarkers, particularly candidate proteins and metabolites, for improving clinical management.

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