Ferroptosis Patterns Modulate Immunocyte Communication in Tumor Microenvironments: Clinical Value and Therapeutic Guidance of Lung Adenocarcinoma

Overview

Journal Funct Integr Genomics

Publisher Springer

Specialties Genetics
Molecular Biology

Date 2023 May 25

PMID 37231311

Authors

Peng Wang

Ye Wang

Yu Wang

Affiliations

Soon will be listed here.

Abstract

Lung adenocarcinoma (LUAD) emerges as one of the most aggressive tumor types with a poor prognosis. As a novel form of regulated cell death, ferroptosis promotes the clearance of tumor cells. However, few studies demonstrated whether ferroptosis-related genes can modify the behavior of tumor microenvironment (TME) cells. Resorting to non-negative matrix factorization (NMF) clustering based on the expression of ferroptosis-related genes, we identified multiple LUAD TME cell-type subpopulations. These subtypes of TME cells displayed extensive communication with tumor epithelial cells. ATF3+cancer-associated fibroblasts (CAFs), SLC40A1+CD8+T cells, and ALOX5+CD8+T cells showed distinct biological features compared to non-ferroptosis-related TME cells. Patients with a higher abundance of these ferroptosis-related TME cell subtypes showed a favorable clinical outcome. Our study depicted a detailed landscape of LUAD cell composition with a focus on ferroptosis-related genes, which, hopefully, may provide novel insight into further study of the LAUD immune microenvironment.

Citing Articles

Regulation of Ferroptosis in Lung Adenocarcinoma.

Wei X, Li X, Hu S, Cheng J, Cai R Int J Mol Sci. 2023; 24(19).

PMID: 37834062 PMC: 10572737. DOI: 10.3390/ijms241914614.

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