Riding Up the EscaLEC-TOR for Valvular Health
Overview
Overview
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Endothelial-lined valves assure unidirectional flow in the lymphatic system. In this issue, Saygili Demir et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202207049) demonstrate how continuous repair of these valves occur, beginning with mTOR-activated cell replication in valve sinuses, and followed by cell migration to cover the valve surface.
References
1.
Niimi K, Nakae J, Inagaki S, Furuyama T
. FOXO1 represses lymphatic valve formation and maintenance via PRDM1. Cell Rep. 2021; 37(9):110048.
DOI: 10.1016/j.celrep.2021.110048.
View
2.
Baluk P, Yao L, Flores J, Choi D, Hong Y, McDonald D
. Rapamycin reversal of VEGF-C-driven lymphatic anomalies in the respiratory tract. JCI Insight. 2017; 2(16).
PMC: 5621869.
DOI: 10.1172/jci.insight.90103.
View
3.
Schmid-Schonbein G
. Microlymphatics and lymph flow. Physiol Rev. 1990; 70(4):987-1028.
DOI: 10.1152/physrev.1990.70.4.987.
View
4.
Scallan J, Knauer L, Hou H, Castorena-Gonzalez J, Davis M, Yang Y
. Foxo1 deletion promotes the growth of new lymphatic valves. J Clin Invest. 2021; 131(14).
PMC: 8279588.
DOI: 10.1172/JCI142341.
View
5.
Saygili Demir C, Sabine A, Gong M, Dormond O, Petrova T
. Mechanosensitive mTORC1 signaling maintains lymphatic valves. J Cell Biol. 2023; 222(6).
PMC: 10097975.
DOI: 10.1083/jcb.202207049.
View