Reciprocal Costimulatory Molecules Control the Activation of Mucosal Type 3 Innate Lymphoid Cells During Engagement with B Cells

Overview

Journal Cell Mol Immunol

Date 2023 May 24

PMID 37225838

Authors

Xinping Lv

Shan Zhu

Jing Wu

Jinfeng Shi

Qiuyu Wei

Tete Li

Ning Yang

Chunyan Liu

Lingli Qi

Guoxia Zang

Hang Cheng

Zhiguang Yang

Chengyan Jin

Yusheng Wang

Jiuwei Cui

Hideki Ueno

Yong-Jun Liu

Jingtao Chen

Affiliations

Soon will be listed here.

Abstract

Innate lymphoid cells (ILCs) are the counterpart of T helper cells in the innate immune system and share multiple phenotypes with T helper cells. Inducible T-cell costimulator (ICOS) is recognized on T cells and participates in T-cell activation and T and B-cell engagement in lymphoid tissues. However, the role of ICOS in ILC3s and ILC3-involved interactions with the immune microenvironment remains unclear. Here, we found that ICOS expression on human ILC3s was correlated with the activated state of ILC3s. ICOS costimulation enhanced the survival, proliferation, and capacity of ILC3s to produce cytokines (IL-22, IL-17A, IFN-γ, TNF, and GM-CSF). Via synergistic effects of ICOS and CD40 signaling, B cells promoted ILC3 functions, and ILC3-induced T-cell-independent B-cell IgA and IgM secretion primarily required CD40 signaling. Hence, ICOS is essential for the nonredundant role of ILC3s and their interaction with adjacent B cells.

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