Anti-leucine-rich Glioma-inactivated 1 Protein-antibody Positive Encephalitis with Extensive Unilateral Cerebral Cortex and White Matter Lesions
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Abstract
Encephalitis caused by antibodies targeting the leucine-rich glioma-inactivated 1 protein receptor, which belongs to the anti-voltage-gated potassium channel receptor complex, is characterized by hyponatremia, progressive cognitive impairment, seizures, and psychiatric disorders. The patient initially presented with faciobrachial dystonic seizures and subsequently developed encephalopathy. Brain magnetic resonance imaging revealed atypical unilateral hyperintense signals in the cerebral cortex and white matter. Intravenous corticosteroid pulse therapy effectively improved faciobrachial dystonic seizures and brain lesions.
References
1.
Chen W, Wang M, Gao L, Huang Z, Lin Y, Xue Q
. Neurofunctional outcomes in patients with anti-leucine-rich glioma inactivated 1 encephalitis. Acta Neurol Scand. 2021; 144(6):632-639.
DOI: 10.1111/ane.13503.
View
2.
van Sonderen A, Thijs R, Coenders E, Jiskoot L, Sanchez E, de Bruijn M
. Anti-LGI1 encephalitis: Clinical syndrome and long-term follow-up. Neurology. 2016; 87(14):1449-1456.
DOI: 10.1212/WNL.0000000000003173.
View
3.
Olszewski C, Thomson S, Strauss L, Graham R, Ezzeddine M, Dodenhoff K
. Patient Experiences With Ambulatory Telehealth in Neurology: Results of a Mixed-Methods Study. Neurol Clin Pract. 2022; 11(6):484-496.
PMC: 8723923.
DOI: 10.1212/CPJ.0000000000001072.
View
4.
Ohkawa T, Fukata Y, Yamasaki M, Miyazaki T, Yokoi N, Takashima H
. Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci. 2013; 33(46):18161-74.
PMC: 3828467.
DOI: 10.1523/JNEUROSCI.3506-13.2013.
View
5.
Ghimire P, Khanal U, Gajurel B, Karn R, Rajbhandari R, Paudel S
. Anti-LGI1, anti-GABABR, and Anti-CASPR2 encephalitides in Asia: A systematic review. Brain Behav. 2020; 10(10):e01793.
PMC: 7559615.
DOI: 10.1002/brb3.1793.
View