The Dynamic Relationship of Gut Microbiota with Sex Hormones in Systemic Lupus Erythematosus

Overview

Journal Reumatologia

Publisher Termedia

Specialty Rheumatology

Date 2023 May 24

PMID 37223365

Authors

Marcel Katrib

Rafi Haddad

Zahi Hamdan

Mohamad Ali Rida

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease. The sex hormones estrogen and testosterone may have an influence on the production of antibodies. In addition, the gut microbiota also shows an effect on the onset and progression of SLE. Hence, the molecular interplay between sex hormones in terms of gender difference, gut microbiota and SLE is being clarified day after day. The aim of this review is to investigate the dynamic relationship of the gut microbiota with sex hormones in systemic lupus erythematosus taking into account the bacterial strains shown to be affected, effects of antibiotics and other factors that affect the gut microbiome, which itself strongly affects the pathogenesis of SLE.

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