A Candidemia Case Caused by a Novel Drug-Resistant with the Y132F Mutation in Erg11 in Mainland China

Overview

Journal Infect Drug Resist

Publisher Dove Medical Press

Date 2023 May 24

PMID 37222986

Authors

Zhaoxia Xu

Lei Zhang

Ran Han

Chengwei Ding

Haochang Shou

Xueguang Duan

Shengwei Zhang

Affiliations

Soon will be listed here.

Abstract

Background: is a pathogen first found in external ear canal, becoming a major threat to global health. Here, we describe a candidemia case caused by a novel drug-resistant strain.

Case Presentation: An 80-year-old patient, with multiple serious medical conditions, was suffered from candidemia caused by , died 9 days after admission in our hospital. Phylogenetic analysis indicates that this isolate (designated BJCA003) belongs to the South Asian clade, carries the Y132F mutation in the protein Erg11. And antibiotic susceptibility test indicated that BJCA003 is resistant to fluconazole and amphotericin B, not susceptible to caspofungin. In addition, this strain has multiple colony and cellular morphologies under different culture conditions.

Conclusion: Strain BJCA003 is a novel drug resistant strain in mainland China, the Y132F mutation in Erg11 may attribute to fluconazole-resistance, alarming that we still face more challenges about

Citing Articles

First report of in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemia.

Peng Y, Liu Y, Yu X, Fang J, Guo Z, Liao K Emerg Microbes Infect. 2024; 13(1):2300525.

PMID: 38164742 PMC: 10773663. DOI: 10.1080/22221751.2023.2300525.

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