Prognostic Factors for Multiple Myeloma in the Dog

Overview

Journal J Am Vet Med Assoc

Specialty Veterinary Medicine

Date 1986 Jun 1

PMID 3721983

Citations 21

Authors

R E Matus

C E Leifer

E G MacEwen

A I Hurvitz

Affiliations

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Abstract

Multiple myeloma was diagnosed in 60 dogs. Diagnosis was confirmed in each case by observation of greater than 5% plasma cells on examination of a bone marrow aspirate and detection of monoclonal gammopathy of immunoglobulin (Ig) A or IgG. Treatment with melphalan, cyclophosphamide, and prednisone was associated with long-term survival (median, 540 days). Response to therapy was significantly related to prognosis (P less than 0.01), whereas hypercalcemia and Ig light chain proteinuria (Bence Jones) were associated with shorter median survival times.

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