Association of Endothelial Nitric Oxide Synthase (Glu298Asp) Gene Polymorphism with Radial Artery Spasm During Cardiac Catheterization in Egyptians

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2023 May 23

PMID 37219667

Authors

Tarek A Abdelaziz

Randa H Mohamed

Ashraf A Dwedar

Mohey Eldeen A Eldeeb

Abdelrahman A Abdelfattah

Sara F Saadawy

Affiliations

Soon will be listed here.

Abstract

Background: Nitric oxide (NO) exerts diverse effects on the cardiovascular system. Impairment of NO production plays a key role in cerebral and coronary artery spasm. We aimed to explore the predicting factors of radial artery spasm (RAS) and the association of eNOS gene polymorphism (Glu298Asp) with RAS during cardiac catheterization.

Methods And Results: 200 patients underwent elective coronary angiography through a trans-radial approach. The subjects were genotyped to the Glu298Asp polymorphism (rs1799983) on the eNOS gene by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Our results showed that the subjects with the TT genotype and T allele were significantly more likely to develop radial artery spasms (OR = 12.5, 4.6, P < 0.001 respectively). TT genotype of eNOS Glu298Asp polymorphism, number of punctures, size of the radial sheath, radial tortuosity, and right radial access are independent predictors of radial spasm.

Conclusion: The eNOS (Glu298Asp) gene polymorphism is associated with RAS during cardiac catheterization in Egyptians. TT genotype of eNOS Glu298Asp polymorphism, number of punctures, size of the radial sheath, right radial access, and tortuosity are independent predictors of RAS during cardiac catheterization.

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