Relationship Between Leptin and White Blood Cells: a Potential Role in Infection Susceptibility and Severity-the Olivetti Heart Study

Overview

Journal Intern Emerg Med

Publisher Springer

Specialties Emergency Medicine
General Medicine

Date 2023 May 22

PMID 37217748

Authors

Lanfranco DElia

Maria Masulli

Roberto Iacone

Ornella Russo

Pasquale Strazzullo

Ferruccio Galletti

Affiliations

Soon will be listed here.

Abstract

A number of evidence showed an emerging role of leptin on immune system, involving inflammation, and innate and adaptive immunity. Few observational studies have evaluated the relationship between leptin and immunity, albeit with low statistical power and methodological differences. Therefore, the aim of this study was to evaluate the potential role of leptin on the immunity, expressed as white blood cells (WBC)-and its subpopulations, by comprehensive multivariate models in a sample of adult men. A cross-sectional evaluation of a general population comprised 939 subjects participating in the Olivetti Heart Study, with available leptin levels and WBC-and its subpopulations. WBC were significantly and positively associated with leptin, C-reactive protein and HOMA index (p < 0.05), but not with age and anthropometric indices (p > 0.05). The multivariate analysis confirmed the association between leptin and WBC, after accounting for main confounders (p < 0.05). Additional analysis on WBC subpopulations showed a positive and significant correlation between leptin and lymphocytes, monocytes and eosinophils (p < 0.05), but not with neutrophils and basophils (p > 0.05). After stratification by body weight, the positive and significant association between leptin and WBC-and its subpopulations-was found in excess body weight participants. The results of this study indicate a direct relationship between leptin levels and WBC-and its subpopulations-in excess body weight participants. These results support the hypothesis that leptin has modulatory functions on immunity and role in the pathophysiology of immune-related diseases, in particular in those associated with excess body weight.

References

Considine R, Sinha M, Heiman M, Kriauciunas A, STEPHENS T, Nyce M . Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996; 334(5):292-5. DOI: 10.1056/NEJM199602013340503. View

Haynes W . Role of leptin in obesity-related hypertension. Exp Physiol. 2005; 90(5):683-8. DOI: 10.1113/expphysiol.2005.031237. View

Lahlou N, Clement K, Carel J, Vaisse C, Lotton C, Le Bihan Y . Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. Diabetes. 2000; 49(8):1347-52. DOI: 10.2337/diabetes.49.8.1347. View

Galletti F, DElia L, Barba G, Siani A, Cappuccio F, Farinaro E . High-circulating leptin levels are associated with greater risk of hypertension in men independently of body mass and insulin resistance: results of an eight-year follow-up study. J Clin Endocrinol Metab. 2008; 93(10):3922-6. DOI: 10.1210/jc.2008-1280. View

DElia L, Strazzullo P, Iacone R, Russo O, Galletti F . Leptin levels predict the development of insulin resistance in a sample of adult men-The Olivetti Heart Study. Nutr Metab Cardiovasc Dis. 2018; 29(1):39-44. DOI: 10.1016/j.numecd.2018.10.003. View

DElia L, Manfredi M, Perna L, Iacone R, Russo O, Strazzullo P . Circulating leptin levels predict the decline in renal function with age in a sample of adult men (The Olivetti Heart Study). Intern Emerg Med. 2018; 14(4):507-513. DOI: 10.1007/s11739-018-1924-9. View

DElia L, Giaquinto A, Cappuccio F, Iacone R, Russo O, Strazzullo P . Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men. J Endocrinol Invest. 2019; 43(5):587-593. DOI: 10.1007/s40618-019-01140-4. View

DElia L, Giaquinto A, de Simone G, Iacone R, Russo O, Strazzullo P . Leptin levels predict the development of left ventricular hypertrophy in a sample of adult men: the Olivetti Heart Study. J Hypertens. 2020; 39(4):692-697. DOI: 10.1097/HJH.0000000000002687. View

Perez-Perez A, Vilarino-Garcia T, Fernandez-Riejos P, Martin-Gonzalez J, Segura-Egea J, Sanchez-Margalet V . Role of leptin as a link between metabolism and the immune system. Cytokine Growth Factor Rev. 2017; 35:71-84. DOI: 10.1016/j.cytogfr.2017.03.001. View

10.

Guglielmi V, Colangeli L, DAdamo M, Sbraccia P . Susceptibility and Severity of Viral Infections in Obesity: Lessons from Influenza to COVID-19. Does Leptin Play a Role?. Int J Mol Sci. 2021; 22(6). PMC: 8003928. DOI: 10.3390/ijms22063183. View

11.

Dessie G, Ayelign B, Akalu Y, Shibabaw T, Molla M . Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication. Diabetes Metab Syndr Obes. 2021; 14:3307-3322. PMC: 8296717. DOI: 10.2147/DMSO.S321311. View

12.

Tilg H, Moschen A . Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006; 6(10):772-83. DOI: 10.1038/nri1937. View

13.

Iikuni N, Lam Q, Lu L, Matarese G, La Cava A . Leptin and Inflammation. Curr Immunol Rev. 2011; 4(2):70-79. PMC: 2829991. DOI: 10.2174/157339508784325046. View

14.

Shapiro N, Khankin E, van Meurs M, Shih S, Lu S, Yano M . Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010; 185(1):517-24. PMC: 3997057. DOI: 10.4049/jimmunol.0903975. View

15.

Ubags N, Vernooy J, Burg E, Hayes C, Bement J, Dilli E . The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med. 2013; 42(2):e143-51. PMC: 3947045. DOI: 10.1097/CCM.0000000000000048. View

16.

Guo X, Roberts M, Becker S, Podd B, Zhang Y, Chua Jr S . Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica. Mucosal Immunol. 2010; 4(3):294-303. PMC: 3079783. DOI: 10.1038/mi.2010.76. View

17.

Mabuchi T, Yatsuya H, Tamakoshi K, Otsuka R, Nagasawa N, Zhang H . Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. Diabetes Metab Res Rev. 2005; 21(5):441-7. DOI: 10.1002/dmrr.540. View

18.

Chung F, Tsai J, Chang D, Shin S, Lee Y . Peripheral total and differential leukocyte count in diabetic nephropathy: the relationship of plasma leptin to leukocytosis. Diabetes Care. 2005; 28(7):1710-7. DOI: 10.2337/diacare.28.7.1710. View

19.

Laharrague P, Oppert J, Brousset P, Charlet J, Campfield A, Fontanilles A . High concentration of leptin stimulates myeloid differentiation from human bone marrow CD34+ progenitors: potential involvement in leukocytosis of obese subjects. Int J Obes Relat Metab Disord. 2000; 24(9):1212-6. DOI: 10.1038/sj.ijo.0801377. View

20.

Wilson C, Bekele G, Nicolson M, Ravussin E, Pratley R . Relationship of the white blood cell count to body fat: role of leptin. Br J Haematol. 1997; 99(2):447-51. DOI: 10.1046/j.1365-2141.1997.3873201.x. View