MicroRNA-31 Induced by Infection Promotes Colorectal Cancer Tumorigenesis

Overview

Journal iScience

Publisher Cell Press

Date 2023 May 22

PMID 37216106

Authors

Bin Tang

Xiaoxue Lu

Yanan Tong

Yuyang Feng

Yilan Mao

Guodong Dun

Jing Li

Qiaolin Xu

Jie Tang

Tao Zhang

Ling Deng

Xiaoyi He

Yuanzhi Lan

Huaxing Luo

Linghai Zeng

Yuanyuan Xiang

Qian Li

Dongzhu Zeng

Xuhu Mao

Affiliations

Soon will be listed here.

Abstract

Persistent infection is associated with the development of human colorectal cancer (CRC) and promotes tumorigenicity, but the underlying mechanisms remain unclear. Here, we reported that promoted the tumorigenicity of CRC, which was associated with -induced microRNA-31 (miR-31) expression in CRC tissues and cells. infection inhibited autophagic flux by miR-31 through inhibiting syntaxin-12 (STX12) and was associated with the increased intracellular survival of . Overexpression of miR-31 in CRC cells promoted their tumorigenicity by targeting eukaryotic initiation factor 4F-binding protein 1/2 (eIF4EBP1/2), whereas miR-31 knockout mice were resistant to the formation of colorectal tumors. In conclusion, , miR-31, and STX12 form a closed loop in the autophagy pathway, and continuous -induced miR-31 expression promotes the tumorigenicity of CRC cells by targeting eIF4EBP1/2. These findings reveal miR-31 as a potential diagnostic biomarker and therapeutic target in CRC patients with infection.

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