Development and Validation of a Collagen Signature to Predict the Prognosis of Patients with Stage II/III Colorectal Cancer

Overview

Journal iScience

Publisher Cell Press

Date 2023 May 22

PMID 37216096

Authors

Shumin Dong

Huaiming Wang

Hongli Ji

Yaowen Hu

Shuhan Zhao

Botao Yan

Guangxing Wang

Zexi Lin

Weifeng Zhu

Jianping Lu

Jiaxin Cheng

Zhida Wu

Qiong Zhu

Shuangmu Zhuo

Gang Chen

Jun Yan

Affiliations

Soon will be listed here.

Abstract

The tumor, nodes and metastasis (TNM) classification system provides useful but incomplete prognostic information and lacks the assessment of the tumor microenvironment (TME). Collagen, the main component of the TME extracellular matrix, plays a nonnegligible role in tumor invasion and metastasis. In this cohort study, we aimed to develop and validate a TME collagen signature (CS) for prognostic prediction of stage II/III colorectal cancer (CRC) and to compare the prognostic values of "TNM stage + CS" with that of TNM stage alone. Results indicated that the CS was an independent prognostic risk factor for stage II/III CRC (hazard ratio: 2.939, 95% CI: 2.180-3.962, p < 0.0001), and the integration of the TNM stage and CS had a better prognostic value than that of the TNM stage alone (AUC = 0.772, AUC = 0.687, p < 0.0001). This study provided an application of "seed and soil" strategy for prognosis prediction and individualized therapy.

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