Oncogenic Roles and Related Mechanisms of the Long Non-coding RNA MINCR in Human Cancers

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 May 22

PMID 37215074

Authors

Ce Chao

Renzhe Tang

Jiamin Zhao

Dongmei Di

Yongxiang Qian

Bin Wang

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) play vital roles in regulating epigenetic mechanisms and gene expression levels, and their dysregulation is closely associated with a variety of diseases such as cancer. Several studies have demonstrated that lncRNAs are dysregulated during tumor progression. Recently, the MYC-induced long non-coding RNA MINCR, a newly identified lncRNA, has been demonstrated to act as an oncogene in different cancers, including gallbladder cancer, hepatocellular cancer, colorectal cancer, non-small cell lung cancer, oral squamous cell carcinoma, nasopharyngeal cancer, and glioma. Moreover, MINCR has been reported to act as a biomarker in the prognosis of patients with different cancers. In this review, we summarize and analyze the oncogenic roles of MINCR in a variety of human cancers in terms of its clinical significance, biological functions, cellular activities, and regulatory mechanism. Our analysis of the literature suggests that MINCR has potential as a novel biomarker and therapeutic target in human cancers.

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