Multi-frame Biomechanical and Relaxometry Analysis During in Vivo Loading of the Human Knee by Spiral DualMRI and Compressed Sensing

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2023 May 22

PMID 37213087

Authors

Woowon Lee

Emily Y Miller

Hongtian Zhu

Stephanie E Schneider

David A Reiter

Corey P Neu

Affiliations

Soon will be listed here.

Abstract

Purpose: Knee cartilage experiences repetitive loading during physical activities, which is altered during the pathogenesis of diseases like osteoarthritis. Analyzing the biomechanics during motion provides a clear understanding of the dynamics of cartilage deformation and may establish essential imaging biomarkers of early-stage disease. However, in vivo biomechanical analysis of cartilage during rapid motion is not well established.

Methods: We used spiral displacement encoding with stimulated echoes (DENSE) MRI on in vivo human tibiofemoral cartilage during cyclic varus loading (0.5 Hz) and used compressed sensing on the k-space data. The applied compressive load was set for each participant at 0.5 times body weight on the medial condyle. Relaxometry methods were measured on the cartilage before (T , T ) and after (T ) varus load.

Results: Displacement and strain maps showed a gradual shift of displacement and strain in time. Compressive strain was observed in the medial condyle cartilage and shear strain was roughly half of the compressive strain. Male participants had more displacement in the loading direction compared to females, and T values did not change after cyclic varus load. Compressed sensing reduced the scanning time up to 25% to 40% when comparing the displacement maps and substantially lowered the noise levels.

Conclusion: These results demonstrated the ease of which spiral DENSE MRI could be applied to clinical studies because of the shortened imaging time, while quantifying realistic cartilage deformations that occur through daily activities and that could serve as biomarkers of early osteoarthritis.

Citing Articles

Updates on Compositional MRI Mapping of the Cartilage: Emerging Techniques and Applications.

Zibetti M, Menon R, De Moura H, Zhang X, Kijowski R, Regatte R J Magn Reson Imaging. 2023; 58(1):44-60.

PMID: 37010113 PMC: 10323700. DOI: 10.1002/jmri.28689.

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