Aβ Induces Neuroinflammation and Microglial M1 Polarization Via CGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2023 May 20

PMID 37210413

Authors

Zheng Wu

Wei Tang

Fatima Elzahra E M Ibrahim

Xuejing Chen

Hongting Yan

Chunmei Tao

Zhiming Wang

Yunchu Guo

Yu Fu

Qi Wang

Yusong Ge

Affiliations

Soon will be listed here.

Abstract

Microglia, innate immune cells of the brain, constantly monitor the dynamic changes of the brain microenvironment under physiological conditions and respond in time. Growing evidence suggests that microglia-mediated neuroinflammation plays an important role in the pathogenesis of Alzheimer's disease. In this study, we investigated that the expression of IFITM3 was significantly upregulated in microglia under the Aβ treatment, and knockdown of IFITM3 in vitro suppressed the M1-like polarization of microglia. Moreover, IFITM3 was regulated by cGAS-STING signaling in activated microglia, and inhibition of cGAS-STING signaling reduces IFITM3 expression. Taken together, our findings suggested that the cGAS-STING-IFITM3 axis may be involved in Aβ-induced neuroinflammation in microglia.

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