Powell Lens-based Line-field Spectral Domain Optical Coherence Tomography System for Cellular Resolution Imaging of Biological Tissue

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2023 May 19

PMID 37206146

Authors

Keyu Chen

Weixiang Song

Le Han

Kostadinka Bizheva

Affiliations

Soon will be listed here.

Abstract

A Powell lens is used in a line-field spectral domain OCT (PL-LF-SD-OCT) system to generate a line-shaped imaging beam with almost uniform distribution of the optical power in the line direction. This design overcomes the severe sensitivity loss (∼10 dB) observed along the line length direction (B-scan) in LF-OCT systems based on cylindrical lens line generators. The PL-LF-SD-OCT system offers almost isotropic spatial resolution (Δx and Δy ∼2 µm, Δz ∼1.8 µm) in free space and sensitivity of ∼87 dB for 2.5 mW imaging power at 2,000 fps imaging rate with only ∼1.6 dB sensitivity loss along the line length. Images acquired with the PL-LF-SD-OCT system allow for visualization of the cellular and sub-cellular structure of biological tissues.

Citing Articles

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