Cross-Coupling of Amines Via Photocatalytic Denitrogenation of In Situ Generated Diazenes

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2023 May 18

PMID 37201211

Authors

Keri A Steiniger

Matthew C Lamb

Tristan H Lambert

Affiliations

Soon will be listed here.

Abstract

A method for C(sp)-C(sp) cross-coupling of amines is described. Primary amines are converted to 1,2-dialkyldiazenes by treatment with -nosylhydroxylamines in the presence of atmospheric oxygen. Denitrogenation of the diazenes with an iridium photocatalyst then forges the C-C bond. The substrate scope accommodates a broad latitude of functionality, including heteroaromatics and unprotected alcohols and acids.

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