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Colorectal Cancer Diagnostic Methods: The Present and Future

Overview
Journal Cureus
Date 2023 May 17
PMID 37197135
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Abstract

To meet the needs of the colorectal cancer (CRC) patient population, colorectal cancer screening is continuously updated. The most significant advice is to start CRC screening exams at age 45 for people at average risk for CRC. CRC testing is divided into two categories: stool-based tests and visual inspections. High-sensitivity guaiac-based fecal occult blood testing, fecal immunochemical testing, and multitarget stool DNA testing are stool-based assays. Colon capsule endoscopy and flexible sigmoidoscopy are visualization examinations. There have been arguments about the importance of these tests in detecting and managing precursor lesions because of the lack of validation of screening results. Recent advancements in artificial intelligence and genetics have prompted the creation of newer diagnostic tests, which require validation in diverse populations and cohorts. In this article, we have discussed the present and emerging diagnostic tests.

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References
1.
Bosch L, Melotte V, Mongera S, Daenen K, Coupe V, van Turenhout S . Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population. Am J Gastroenterol. 2019; 114(12):1909-1918. PMC: 6903367. DOI: 10.14309/ajg.0000000000000445. View

2.
Lee M, Loree J . Current and emerging biomarkers in metastatic colorectal cancer. Curr Oncol. 2019; 26(Suppl 1):S7-S15. PMC: 6878935. DOI: 10.3747/co.26.5719. View

3.
Al-Joufi F, Setia A, Salem-Bekhit M, Sahu R, Alqahtani F, Widyowati R . Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches. Nanomaterials (Basel). 2022; 12(1). PMC: 8746463. DOI: 10.3390/nano12010169. View

4.
Allison J, Fraser C, Halloran S, Young G . Population screening for colorectal cancer means getting FIT: the past, present, and future of colorectal cancer screening using the fecal immunochemical test for hemoglobin (FIT). Gut Liver. 2014; 8(2):117-30. PMC: 3964261. DOI: 10.5009/gnl.2014.8.2.117. View

5.
Okugawa Y, Grady W, Goel A . Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers. Gastroenterology. 2015; 149(5):1204-1225.e12. PMC: 4589488. DOI: 10.1053/j.gastro.2015.07.011. View