Dopaminergic System in Promoting Recovery from General Anesthesia

Overview

Journal Brain Sci

Publisher MDPI

Date 2023 May 16

PMID 37190503

Authors

Jinxu Wang

Xiaolei Miao

Yi Sun

Sijie Li

Anshi Wu

Changwei Wei

Affiliations

Soon will be listed here.

Abstract

Dopamine is an important neurotransmitter that plays a biological role by binding to dopamine receptors. The dopaminergic system regulates neural activities, such as reward and punishment, memory, motor control, emotion, and sleep-wake. Numerous studies have confirmed that the dopaminergic system has the function of maintaining wakefulness in the body. In recent years, there has been increasing evidence that the sleep-wake cycle in the brain has similar neurobrain network mechanisms to those associated with the loss and recovery of consciousness induced by general anesthesia. With the continuous development and innovation of neurobiological techniques, the dopaminergic system has now been proved to be involved in the emergence from general anesthesia through the modulation of neuronal activity. This article is an overview of the dopaminergic system and the research progress into its role in wakefulness and general anesthesia recovery. It provides a theoretical basis for interpreting the mechanisms regulating consciousness during general anesthesia.

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