Effects of a Physical Exercise or Motor Activity Protocol on Cognitive Function, Lipid Profile, and BDNF Levels in Older Adults with Mild Cognitive Impairment

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2023 May 15

PMID 37186275

Authors

Clodoaldo Antonio De Sa

Chrystianne Barros Saretto

Andreia Machado Cardoso

Aline Remor

Christian Ouriques Breda

Vanessa da Silva Corralo

Affiliations

Soon will be listed here.

Abstract

This study analyzed the effects of a physical exercise program compared to the complexity of the motor task on the cognitive function, brain-derived neurotrophic factor (BDNF) levels, and lipid profile of older adults with mild cognitive impairment (MCI). Twenty-seven participants were randomized into three intervention groups: Physical Exercise (PE), Motor Task (MT), and Physical Exercise associated with Motor Task (PE + MT). Six months of intervention twice a week resulted in improvements in cognitive function, total cholesterol (TC), and LDL cholesterol (LDL-C) in the PE (p < 0.05). In the PE + MT, in addition to improved cognitive capacity, there was also a reduction in non-HDL cholesterol (NHDL-C) and LDL cholesterol (LDL-C) levels (p < 0.05), while in the MT, the values of TC, NHDL-C, and LDL-C decreased as a result of the intervention. BDNF levels were not affected by the interventions. In conclusion, PE alone or combined with MT is effective in promoting improvements in overall cognitive function and lipid profile in older adults with MCI; and BDNF seems not to be a sensitive marker for people with mild cognitive impairment.

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