Association of Trajectories of Non-high-density Lipoprotein Cholesterol Concentration with Risk of Cardiovascular Disease: the Kailuan Study

Overview

Journal BMJ Open

Specialty General Medicine

Date 2023 May 15

PMID 37185179

Authors

Xiong Ding

Hui Zhou

Qing Yue

Zhe Shu

Xiaoxu Ma

Yun Li

Shouling Wu

Affiliations

Soon will be listed here.

Abstract

Objectives: This study aimed to assess the association between longitudinal change in non-high-density lipoprotein cholesterol (non-HDL-C) and subsequent cardiovascular disease (CVD) risk.

Design: A retrospective study.

Setting: Data were obtained from the Kailuan Study, a dynamic cohort study initiated in 2006 in Tangshan, China.

Participants: The current study included 41 085 participants (mean age 53.9±11.6 years) free of CVD events in or before 2012. The non-HDL-C trajectory was developed according to the repeated measurement during 2006-2012 surveys to predict the CVD risk from 2012 to 2020.

Primary Outcome Measures: CVD events included myocardial infarction and stroke.

Results: 3 discrete non-HDL-C trajectories were identified: low-increasing (n=20 038), moderate-increasing (n=17 987) and high-increasing (n=3060). During 8 years of follow-up, 1797 CVD events were documented. Relative to the low-increasing pattern, adjusted HRs were 1.25 (95% CI: 1.13 to 1.38) for the moderate-increasing pattern and 1.46 (95% CI: 1.24 to 1.71) for the high-increasing pattern after adjustment for potential confounders such as age, sex, education background, smoking status, drinking status, physical activity, body mass index, low-density lipoprotein cholesterol, hypertension, diabetes and lipid-lowering medications.

Conclusions: Changes in non-HDL-C were significantly associated with subsequent risk of CVD events, and participants with a high-increasing pattern had a higher CVD risk. Long-term monitoring of non-HDL-C could be useful to improve the prediction of CVD risk.

Trial Registration Number: ChiCTR-TNC-1100148.

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