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Co-infection of Leishmania Infantum and a Crithidia-related Species in a Case of Refractory Relapsed Visceral Leishmaniasis with Non-ulcerated Cutaneous Manifestation in Brazil

Overview
Journal Int J Infect Dis
Publisher Elsevier
Specialty Infectious Diseases
Date 2023 May 14
PMID 37182549
Authors
Luana Aparecida Rogerio
Talita Yuri Takahashi
Luria Cardoso
Nayore Tamie Takamiya
Enaldo Vieira de Melo
Amelia Ribeiro de Jesus
Fabricia Alvisi de Oliveira
Sarah Forrester
Daniel C Jeffares
Joao Santana da Silva
Jose Marcos Ribeiro
Roque Pacheco Almeida
Sandra Regina Maruyama
Affiliations
Soon will be listed here.
Abstract

We report a refractory and relapsed visceral leishmaniasis case in a male child patient followed from 2016 to 2020, whose clinical isolates from multiple relapses were analyzed at the genome level. To the best of our knowledge, it is the first report that both visceral leishmaniasis and non-ulcerated cutaneous leishmaniasis have concomitantly manifested in the same patient. Importantly, sequence analysis revealed that the patient was co-infected with Leishmania infantum and a Crithidia-related parasite, which was previously found in a fatal case of visceral leishmaniasis from the same endemic region.

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