Association Between Excessive Fetal Growth and Maternal Cancer in Shanghai, China: a Large, Population-based Cohort Study

Overview

Journal Sci Rep

Specialty Science

Date 2023 May 13

PMID 37179417

Authors

Naisi Qian

Qing Yang

Lei Chen

Shan Jin

Jiaying Qiao

Renzhi Cai

Chunxiao Wu

Huiting Yu

Kai Gu

Chunfang Wang

Affiliations

Soon will be listed here.

Abstract

The prevalence of high birth weight or large for gestational age (LGA) infants is increasing, with increasing evidence of pregnancy-related factors that may have long-term impacts on the health of the mother and baby. We aimed to determine the association between excessive fetal growth, specifically LGA and macrosomia, and subsequent maternal cancer by performing a prospective population-based cohort study. The data set was based on the Shanghai Birth Registry and Shanghai Cancer Registry, with medical records from the Shanghai Health Information Network as a supplement. Macrosomia and LGA prevalence was higher in women who developed cancer than in women who did not. Having an LGA child in the first delivery was associated with a subsequently increased risk of maternal cancer (hazard ratio [HR] = 1.08, 95% confidence interval [CI] 1.04-1.11). Additionally, in the last and heaviest deliveries, there were similar associations between LGA births and maternal cancer rates (HR = 1.08, 95% CI 1.04-1.12; HR = 1.08, 95% CI 1.05-1.12, respectively). Furthermore, a substantially increased trend in the risk of maternal cancer was associated with birth weights exceeding 2500 g. Our study supports the association between LGA births and increased risks of maternal cancer, but this risk requires further investigation.

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