Role of the Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 May 13

PMID 37175983

Authors

Aneta Sciezynska

Krzysztof Luszczynski

Marcin Radziszewski

Michal Komorowski

Marta Soszynska

Natalia Krzesniak

Kateryna Shevchenko

Anna Lutynska

Jacek Malejczyk

Affiliations

Soon will be listed here.

Abstract

The gene encodes an ATP-binding cassette transporter that is expressed specifically in the disc of photoreceptor outer segments. Mutations in the gene are the main cause of retinal degenerations known as "-retinopathies." Recent research has revealed that is expressed in other cells as well, such as hair follicles and keratinocytes, although no information on its significance has been evidenced so far. In this study, we investigated the role of the gene in human keratinocytes and hair follicle stem cells for the first time. We have shown that silencing the gene increases the deleterious effect of all-trans-retinal on human hair follicle stem cells.

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