Quality Control and Analytic Best Practices for Testing Genetic Models of Sex Differences in Large Populations

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2023 May 12

PMID 37172561

Authors

Ekaterina A Khramtsova

Melissa A Wilson

Joanna Martin

Stacey J Winham

Karen Y He

Lea K Davis

Barbara E Stranger

Affiliations

Soon will be listed here.

Abstract

Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are becoming increasingly important for understanding the mechanisms driving these differences. To this end, we provide a guide outlining the current best practices for testing various models of sex-dependent genetic effects in complex traits and disease conditions, noting that this is an evolving field. Insights from sex-aware analyses will not only teach us about the biology of complex traits but also aid in achieving the goals of precision medicine and health equity for all.

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