Autophagy in Hepatic Macrophages Can Be Regulator and Potential Therapeutic Target of Liver Diseases: A Review

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2023 May 12

PMID 37171337

Authors

Jun Ge

Hao Li

Jia-Qi Yang

Yuan Yue

Sheng-Yu Lu

Hong-Yun Nie

Tao Zhang

Pei-Ming Sun

Hong-Feng Yan

Hong-Wei Sun

Jian-Wu Yang

Jin-Lian Zhou

Yan Cui

Affiliations

Soon will be listed here.

Abstract

Hepatic macrophages are a complex population of cells that play an important role in the normal functioning of the liver and in liver diseases. Autophagy, as a maintainer of cellular homeostasis, is closely connected to many liver diseases. And its roles are not always beneficial, but manifesting as a double-edged sword. The polarization of macrophages and the activation of inflammasomes are mediated by intracellular and extracellular signals, respectively, and are important ways for macrophages to take part in a variety of liver diseases. More attention should be paid to autophagy of hepatic macrophages in liver diseases. In this review, we focus on the regulatory role of hepatic macrophages' autophagy in a variety of liver diseases; especially on the upstream regulator of polarization and inflammasomes activation of the hepatic macrophages. We believe that the autophagy of hepatic macrophages can become a potential therapeutic target for management of liver diseases.

Citing Articles

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PMID: 39175576 PMC: 11338765. DOI: 10.3389/fendo.2024.1374644.

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