Neuronal Overexpression of HTDP-43 in Mimics the Cellular Pathology Commonly Observed in TDP-43 Proteinopathies

Overview

Journal MicroPubl Biol

Specialty Biology

Date 2023 May 9

PMID 37159575

Authors

Mandy Koopman

Lale Gungordu

Renee I Seinstra

Wytse Hogewerf

Ellen A A Nollen

Affiliations

Soon will be listed here.

Abstract

Inclusions consisting of transactive response DNA-binding protein 43 (TDP-43) are a characteristic feature of amyotrophic lateral sclerosis (ALS). has been instrumental in studying the underlying mechanisms of TDP-43 pathology. Here, we extend the possibilities of previous studies by examining a model expressing human wild-type ( ) pan-neuronally. We show that disease-related (hyper)phosphorylation and cytosolic localisation of hTDP-43 are present in hTDP-43 worms and that these features can be enhanced by adjusting the environmental temperature.

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