Phosphorylation of PSD-95 at Serine 73 in DCA1 is Required for Extinction of Contextual Fear

Overview

Journal PLoS Biol

Specialty Biology

Date 2023 May 8

PMID 37155709

Authors

Magdalena Ziolkowska

Malgorzata Borczyk

Anna Caly

Kamil F Tomaszewski

Agata Nowacka

Maria Nalberczak-Skora

Malgorzata Alicja Sliwinska

Kacper Lukasiewicz

Edyta Skonieczna

Tomasz Wojtowicz

Jakub Wlodarczyk

Tytus Bernas

Ahmad Salamian

Kasia Radwanska

Affiliations

Soon will be listed here.

Abstract

The updating of contextual memories is essential for survival in a changing environment. Accumulating data indicate that the dorsal CA1 area (dCA1) contributes to this process. However, the cellular and molecular mechanisms of contextual fear memory updating remain poorly understood. Postsynaptic density protein 95 (PSD-95) regulates the structure and function of glutamatergic synapses. Here, using dCA1-targeted genetic manipulations in vivo, combined with ex vivo 3D electron microscopy and electrophysiology, we identify a novel, synaptic mechanism that is induced during attenuation of contextual fear memories and involves phosphorylation of PSD-95 at Serine 73 in dCA1. Our data provide the proof that PSD-95-dependent synaptic plasticity in dCA1 is required for updating of contextual fear memory.

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