Developmental Exposure to Corn Grown on Lake Erie Dredged Material: a Preliminary Analysis

Overview

Journal Front Behav Neurosci

Specialty Psychology

Date 2023 May 8

PMID 37153937

Authors

Kaylyn A S Flanigan

Madelyn I Czuba

Victoria R Riesgo

Megan A Rua

Louise M Stevenson

Jari Willing

Affiliations

Soon will be listed here.

Abstract

While corn is considered to be a healthy food option, common agricultural practices, such as the application of soil amendments, might be introducing contaminants of concern (COC) into corn plants. The use of dredged material, which contain contaminants such as heavy metals, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), as a soil amendment is increasing. Contaminants from these amendments can accumulate in corn kernels harvested from plants grown on these sediments and potentially biomagnify in organisms that consume them. The extent to which secondary exposure to such contaminants in corn affect the mammalian central nervous system has been virtually unexplored. In this preliminary study, we examine the effects of exposure to corn grown in dredge amended soil or a commercially available feed corn on behavior and hippocampal volume in male and female rats. Perinatal exposure to dredge-amended corn altered behavior in the open-field and object recognition tasks in adulthood. Additionally, dredge-amended corn led to a reduction in hippocampal volume in male but not female adult rats. These results suggest the need for future studies examining how dredge-amended crops and/or commercially available feed corn may be exposing animals to COC that can alter neurodevelopment in a sex-specific manner. This future work will provide insight into the potential long-term consequences of soil amendment practices on the brain and behavior.

References

Lister R . The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl). 1987; 92(2):180-5. DOI: 10.1007/BF00177912. View

Gore A, Moore T, Groom M, Thompson L . Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats. Toxics. 2022; 10(3). PMC: 8954446. DOI: 10.3390/toxics10030122. View

Remaud S, Gothie J, Morvan-Dubois G, Demeneix B . Thyroid hormone signaling and adult neurogenesis in mammals. Front Endocrinol (Lausanne). 2014; 5:62. PMC: 4009442. DOI: 10.3389/fendo.2014.00062. View

Cory-Slechta D . Studying toxicants as single chemicals: does this strategy adequately identify neurotoxic risk?. Neurotoxicology. 2005; 26(4):491-510. DOI: 10.1016/j.neuro.2004.12.007. View

Das L, Patel B, Patri M . Adolescence benzo[a]pyrene treatment induces learning and memory impairment and anxiolytic like behavioral response altering neuronal morphology of hippocampus in adult male Wistar rats. Toxicol Rep. 2019; 6:1104-1113. PMC: 6838974. DOI: 10.1016/j.toxrep.2019.10.014. View

Bernal J . Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007; 3(3):249-59. DOI: 10.1038/ncpendmet0424. View

Rao Barkur R, Bairy L . Comparison of the developmental milestones and preweaning neurobehavioral parameters in rat pups exposed to lead (Pb) during gestation, lactation and pregestation period. Drug Chem Toxicol. 2015; 39(3):248-55. DOI: 10.3109/01480545.2015.1082136. View

Karlsson O, Roman E, Berg A, Brittebo E . Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-L-alanine) during the neonatal period. Behav Brain Res. 2011; 219(2):310-20. DOI: 10.1016/j.bbr.2011.01.056. View

Ennaceur A, Delacour J . A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. Behav Brain Res. 1988; 31(1):47-59. DOI: 10.1016/0166-4328(88)90157-x. View

10.

Bushnell P, Moser V, MacPhail R, Oshiro W, Derr-Yellin E, Phillips P . Neurobehavioral assessments of rats perinatally exposed to a commercial mixture of polychlorinated biphenyls. Toxicol Sci. 2002; 68(1):109-20. DOI: 10.1093/toxsci/68.1.109. View

11.

Tartar J, Ward C, Cordeira J, Legare S, Blanchette A, McCarley R . Experimental sleep fragmentation and sleep deprivation in rats increases exploration in an open field test of anxiety while increasing plasma corticosterone levels. Behav Brain Res. 2008; 197(2):450-3. PMC: 2632847. DOI: 10.1016/j.bbr.2008.08.035. View

12.

Ennaceur A, Meliani K . A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory. Behav Brain Res. 1992; 51(1):83-92. DOI: 10.1016/s0166-4328(05)80315-8. View

13.

Darmody R, Marlin J, Talbott J, Green R, Brewer E, Stohr C . Dredged Illinois River sediments: plant growth and metal uptake. J Environ Qual. 2004; 33(2):458-64. DOI: 10.2134/jeq2004.4580. View

14.

Hossain S, Bhowmick S, Jahan S, Rozario L, Sarkar M, Islam S . Maternal lead exposure decreases the levels of brain development and cognition-related proteins with concomitant upsurges of oxidative stress, inflammatory response and apoptosis in the offspring rats. Neurotoxicology. 2016; 56:150-158. DOI: 10.1016/j.neuro.2016.07.013. View

15.

Stoltenburg-Didinger G . Neuropathology of the hippocampus and its susceptibility to neurotoxic insult. Neurotoxicology. 1994; 15(3):445-50. View

16.

Sobolewski M, Conrad K, Allen J, Weston H, Martin K, Lawrence B . Sex-specific enhanced behavioral toxicity induced by maternal exposure to a mixture of low dose endocrine-disrupting chemicals. Neurotoxicology. 2014; 45:121-30. PMC: 4387783. DOI: 10.1016/j.neuro.2014.09.008. View

17.

Knudsen E . Sensitive periods in the development of the brain and behavior. J Cogn Neurosci. 2004; 16(8):1412-25. DOI: 10.1162/0898929042304796. View

18.

Elsworth J, Jentsch J, VandeVoort C, Roth R, Redmond Jr D, Leranth C . Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates. Neurotoxicology. 2013; 35:113-20. PMC: 3660149. DOI: 10.1016/j.neuro.2013.01.001. View

19.

Lopez E, Figueroa S, Oset-Gasque M, Gonzalez M . Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture. Br J Pharmacol. 2003; 138(5):901-11. PMC: 1573722. DOI: 10.1038/sj.bjp.0705111. View

20.

Lueptow L . Novel Object Recognition Test for the Investigation of Learning and Memory in Mice. J Vis Exp. 2017; (126). PMC: 5614391. DOI: 10.3791/55718. View