Ferroptosis: Roles and Molecular Mechanisms in Diabetic Cardiomyopathy

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2023 May 8

PMID 37152931

Authors

Yangting Zhao

Binjing Pan

Xiaoyu Lv

Chongyang Chen

Kai Li

Yawen Wang

Jingfang Liu

Affiliations

Soon will be listed here.

Abstract

Diabetic cardiomyopathy (DCM) is a serious complication of type 1 and type 2 diabetes, which leads to the aggravation of myocardial fibrosis, disorders involving systolic and diastolic functions, and increased mortality of patients with diabetes through mechanisms such as glycolipid toxicity, inflammatory response, and oxidative stress. Ferroptosis is a form of iron-dependent regulatory cell death that is attributed to the accumulation of lipid peroxides and an imbalance in redox regulation. Increased production of lipid reactive oxygen species (ROS) during ferroptosis promotes oxidative stress and damages myocardial cells, leading to myocardial systolic and diastolic dysfunction. Overproduction of ROS is an important bridge between ferroptosis and DCM, and ferroptosis inhibitors may provide new targets for the treatment of patients with DCM.

Citing Articles

Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy.

Jiang J, Hu S, Hu K, Xiao L, Lin J, Chen Y Apoptosis. 2025; .

PMID: 40042744 DOI: 10.1007/s10495-025-02090-4.

Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches.

Zhou X, Wang H, Yan B, Nie X, Chen Q, Yang X Cardiovasc Drugs Ther. 2024; .

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Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway.

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Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways.

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Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment.

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