PREVALENCE AND CHARACTERISTICS OF THE POLYCYSTIC OVARIAN SYNDROME IN OVERWEIGHT AND OBESE PREMENOPAUSAL WOMEN

Overview

Journal Acta Endocrinol (Buchar)

Specialty Endocrinology

Date 2023 May 8

PMID 37152875

Authors

P Tsenkova

R Robeva

A Elenkova

S Zacharieva

Affiliations

Soon will be listed here.

Abstract

Context: Polycystic ovarian syndrome (PCOS) is commonly associated with obesity, but the prevalence of the syndrome in obese patients is not well established.

Objective: The present study aims to investigate the prevalence of PCOS among overweight and obese premenopausal women and to evaluate the possible associations between the syndrome and metabolic disturbances in obese patients.

Methods: Medical records of all women referred to a single endocrine center because of obesity and/or metabolic disturbances during a three-year period were analyzed. A total of 262 overweight and obese patients of reproductive age were included in the retrospective study.

Results: The overall prevalence of PCOS using the Rotterdam criteria in the group of overweight and obese women was 26%. The degree of obesity did not influence the PCOS prevalence. Women with PCOS had higher blood glucose and insulin levels after glucose load in comparison to other obese patients despite the younger age.

Conclusions: PCOS is a common finding among obese women seeking endocrine help. The oral glucose tolerance test is an important tool for the early detection of carbohydrate disorders in women with the syndrome. Furthermore, screening for PCOS components might be justified in young obese women with pronounced insulin resistance or dysglycemia.

Citing Articles

ENDOCRINOLOGICAL AND GYNECOLOGICAL PARAMETERS IN ASSESSING INFERTILITY AT REPRODUCTIVE AGE.

Tanase A, Ciocoiu M, Tanase G Acta Endocrinol (Buchar). 2025; 20(2):256-259.

PMID: 39845766 PMC: 11750217. DOI: 10.4183/aeb.2024.256.

Correlation and predictive value of systemic immune-inflammation index for dyslipidemia in patients with polycystic ovary syndrome.

Zhou X, Tian Y, Zhang X BMC Womens Health. 2024; 24(1):564.

PMID: 39420320 PMC: 11487766. DOI: 10.1186/s12905-024-03405-4.

Fertility options after chemotherapy in young premenopausal patients.

Tanase A, Ciocoiu M, Tanase G Acta Endocrinol (Buchar). 2024; 19(3):398-402.

PMID: 38356982 PMC: 10863951. DOI: 10.4183/aeb.2023.398.

References

Veltman-Verhulst S, Goverde A, van Haeften T, Fauser B . Fasting glucose measurement as a potential first step screening for glucose metabolism abnormalities in women with anovulatory polycystic ovary syndrome. Hum Reprod. 2013; 28(8):2228-34. DOI: 10.1093/humrep/det226. View

. 2. Classification and Diagnosis of Diabetes: . Diabetes Care. 2019; 43(Suppl 1):S14-S31. DOI: 10.2337/dc20-S002. View

Pasquali R, Casimirri F . The impact of obesity on hyperandrogenism and polycystic ovary syndrome in premenopausal women. Clin Endocrinol (Oxf). 1993; 39(1):1-16. DOI: 10.1111/j.1365-2265.1993.tb01744.x. View

Miao Z, Alvarez M, Ko A, Bhagat Y, Rahmani E, Jew B . The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance. PLoS Genet. 2020; 16(9):e1009018. PMC: 7515203. DOI: 10.1371/journal.pgen.1009018. View

Alberti K, Eckel R, Grundy S, Zimmet P, Cleeman J, Donato K . Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation;.... Circulation. 2009; 120(16):1640-5. DOI: 10.1161/CIRCULATIONAHA.109.192644. View

Legro R, Arslanian S, Ehrmann D, Hoeger K, Murad M, Pasquali R . Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013; 98(12):4565-92. PMC: 5399492. DOI: 10.1210/jc.2013-2350. View

Yildiz B, Knochenhauer E, Azziz R . Impact of obesity on the risk for polycystic ovary syndrome. J Clin Endocrinol Metab. 2007; 93(1):162-8. PMC: 2190739. DOI: 10.1210/jc.2007-1834. View

Hsu M . Changes in the PCOS phenotype with age. Steroids. 2013; 78(8):761-6. DOI: 10.1016/j.steroids.2013.04.005. View

Alberti K, Zimmet P, Shaw J . Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006; 23(5):469-80. DOI: 10.1111/j.1464-5491.2006.01858.x. View

10.

. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2001; 894:i-xii, 1-253. View

11.

Alvarez-Blasco F, Botella-Carretero J, San Millan J, Escobar-Morreale H . Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Arch Intern Med. 2006; 166(19):2081-6. DOI: 10.1001/archinte.166.19.2081. View

12.

Chen J, Shen S, Tan Y, Xia D, Xia Y, Cao Y . The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. J Ovarian Res. 2015; 8:11. PMC: 4392749. DOI: 10.1186/s13048-015-0139-1. View

13.

Teede H, Misso M, Costello M, Dokras A, Laven J, Moran L . Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018; 110(3):364-379. PMC: 6939856. DOI: 10.1016/j.fertnstert.2018.05.004. View

14.

Webber L, Davies M, Anderson R, Bartlett J, Braat D, Cartwright B . ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016; 31(5):926-37. DOI: 10.1093/humrep/dew027. View

15.

Li H, Lam K, Tam S, Lee V, Yeung T, Cheung P . Screening for dysglycaemia by oral glucose tolerance test should be recommended in all women with polycystic ovary syndrome. Hum Reprod. 2015; 30(9):2178-83. DOI: 10.1093/humrep/dev166. View

16.

Livadas S, Bothou C, Kuliczkowska-Plaksej J, Robeva R, Vryonidou A, Macut J . Can dysglycemia in OGTT be predicted by baseline parameters in patients with PCOS?. Endocr Connect. 2022; 11(4). PMC: 9066574. DOI: 10.1530/EC-21-0358. View

17.

Salley K, Wickham E, Cheang K, Essah P, Karjane N, Nestler J . Glucose intolerance in polycystic ovary syndrome--a position statement of the Androgen Excess Society. J Clin Endocrinol Metab. 2007; 92(12):4546-56. DOI: 10.1210/jc.2007-1549. View

18.

Madani T, Hosseini R, Ramezanali F, Khalili G, Jahangiri N, Ahmadi J . Metabolic syndrome in infertile women with polycystic ovarian syndrome. Arch Endocrinol Metab. 2016; 60(3):199-204. PMC: 10522304. DOI: 10.1590/2359-3997000000135. View

19.

Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale H, Franks S, Gambineri A . The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. Eur J Endocrinol. 2014; 171(4):P1-29. DOI: 10.1530/EJE-14-0253. View

20.

Reyes-Munoz E, Ortega-Gonzalez C, Martinez-Cruz N, Arce-Sanchez L, Estrada-Gutierrez G, Moran C . Association of obesity and overweight with the prevalence of insulin resistance, pre-diabetes and clinical-biochemical characteristics among infertile Mexican women with polycystic ovary syndrome: a cross-sectional study. BMJ Open. 2016; 6(7):e012107. PMC: 4964199. DOI: 10.1136/bmjopen-2016-012107. View