NIR-II Fluorescence Microscopic Bioimaging for Intrahepatic Angiography and the Early Detection of Microlesions

Overview

Journal Front Bioeng Biotechnol

Date 2023 May 8

PMID 37152649

Authors

Nuernisha Alifu

Ting Yan

Jun Li

Lijun Zhu

Abudusalamu Aini

Siyiti Amuti

Juan Wu

Wenjing Qi

Gang Guo

Wenbao Zhang

Xueliang Zhang

Affiliations

Soon will be listed here.

Abstract

Hepatic alveolar echinococcosis (HAE) is caused by the metacestode of , which shows characteristics of malignant tumors with high mortality. However, traditional diagnostic imaging methods are still not sufficient for the recognition of HAE microlesions in the early stages. Near-infrared-II (900-1700 nm, NIR-II) fluorescence microscopic imaging (NIR-II-FMI) has shown great potential for biomedical detection. A novel type of negative target imaging method based on NIR-II-FMI with the assistance of indocyanine green (ICG) was explored. Then, NIR-II-FMI was applied to the early detection of HAE for the first time. The negative targeting NIR-II fluorescence imaging of HAE-infected mice at different stages with the assistance of ICG under 808 nm of laser irradiation was obtained. Especially, HAE microlesions at the early stage were detected clearly. Moreover, clear intrahepatic angiography was achieved under the same NIR-II-FMI system.

References

Alifu N, Zebibula A, Qi J, Zhang H, Sun C, Yu X . Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy. ACS Nano. 2018; 12(11):11282-11293. DOI: 10.1021/acsnano.8b05937. View

Li D, Gao Q, Liu J, Feng Y, Ning W, Dong Y . Knowledge, attitude, and practices (KAP) and risk factors analysis related to cystic echinococcosis among residents in Tibetan communities, Xiahe County, Gansu Province, China. Acta Trop. 2015; 147:17-22. PMC: 4441730. DOI: 10.1016/j.actatropica.2015.02.018. View

Abuseir S, Nagel-Kohl U, Wolken S, Strube C . An immunoblot for detection of Taenia saginata cysticercosis. Parasitol Res. 2013; 112(5):2069-73. DOI: 10.1007/s00436-013-3368-5. View

Wang H, Li J, Guo B, Zhao L, Zhang Z, McManus D . In vitro culture of Echinococcus multilocularis producing protoscoleces and mouse infection with the cultured vesicles. Parasit Vectors. 2016; 9(1):411. PMC: 4960901. DOI: 10.1186/s13071-016-1687-y. View

Wang J, Gao C, Steverding D, Wang X, Shi F, Yang Y . Differential diagnosis of cystic and alveolar echinococcosis using an immunochromatographic test based on the detection of specific antibodies. Parasitol Res. 2013; 112(10):3627-33. DOI: 10.1007/s00436-013-3550-9. View

Qi J, Sun C, Zebibula A, Zhang H, Kwok R, Zhao X . Real-Time and High-Resolution Bioimaging with Bright Aggregation-Induced Emission Dots in Short-Wave Infrared Region. Adv Mater. 2018; 30(12):e1706856. DOI: 10.1002/adma.201706856. View

Li Y, Ma Z, Tuxun T, Li Z, Meng Y, Chen X . The application of laparoscopy combined with indocyanine green fluorescence imaging technique for hepatic cystic echinococcosis. BMC Surg. 2020; 20(1):249. PMC: 7579955. DOI: 10.1186/s12893-020-00911-8. View

Gottstein B, Stojkovic M, Vuitton D, Millon L, Marcinkute A, Deplazes P . Threat of alveolar echinococcosis to public health--a challenge for Europe. Trends Parasitol. 2015; 31(9):407-12. DOI: 10.1016/j.pt.2015.06.001. View

Chen Z, Wang Y, Yang F, Lin Y, Zhou Q, Liao Y . New researches and application progress of commonly used optical molecular imaging technology. Biomed Res Int. 2014; 2014:429198. PMC: 3947735. DOI: 10.1155/2014/429198. View

10.

Yang X, Wang S, Zhang X, Ye C, Wang S, An X . Development of PVA-based microsphere as a potential embolization agent. Mater Sci Eng C Mater Biol Appl. 2022; 135:112677. DOI: 10.1016/j.msec.2022.112677. View

11.

Torgerson P, Keller K, Magnotta M, Ragland N . The global burden of alveolar echinococcosis. PLoS Negl Trop Dis. 2010; 4(6):e722. PMC: 2889826. DOI: 10.1371/journal.pntd.0000722. View

12.

Qu C, Xiao Y, Zhou H, Ding B, Li A, Lin J . Quaternary Ammonium Salt Based NIR-II Probes for Imaging. Adv Opt Mater. 2020; 7(15). PMC: 7517706. DOI: 10.1002/adom.201900229. View

13.

Sonmez Tamer G, Dundar D, Uzuner H, Baydemir C . Evaluation of immunochromatographic test for the detection of antibodies against Echinococcosis granulosus. Med Sci Monit. 2015; 21:1219-22. PMC: 4427020. DOI: 10.12659/MSM.893155. View

14.

Dezsenyi B, Strausz T, Makrai Z, Csomor J, Danka J, Kern P . Autochthonous human alveolar echinococcosis in a Hungarian patient. Infection. 2016; 45(1):107-110. DOI: 10.1007/s15010-016-0918-7. View

15.

Deplazes P, Rinaldi L, Alvarez Rojas C, Torgerson P, Harandi M, Romig T . Global Distribution of Alveolar and Cystic Echinococcosis. Adv Parasitol. 2017; 95:315-493. DOI: 10.1016/bs.apar.2016.11.001. View

16.

Wang J, Jebbawi F, Bellanger A, Beldi G, Millon L, Gottstein B . Immunotherapy of alveolar echinococcosis via PD-1/PD-L1 immune checkpoint blockade in mice. Parasite Immunol. 2018; 40(12):e12596. PMC: 6587932. DOI: 10.1111/pim.12596. View

17.

Mihmanli M, Idiz U, Kaya C, Demir U, Bostanci O, Omeroglu S . Current status of diagnosis and treatment of hepatic echinococcosis. World J Hepatol. 2016; 8(28):1169-1181. PMC: 5055586. DOI: 10.4254/wjh.v8.i28.1169. View

18.

Zhang M, Yue J, Cui R, Ma Z, Wan H, Wang F . Bright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging. Proc Natl Acad Sci U S A. 2018; 115(26):6590-6595. PMC: 6042152. DOI: 10.1073/pnas.1806153115. View

19.

Wu D, Xue D, Zhou J, Wang Y, Feng Z, Xu J . Extrahepatic cholangiography in near-infrared II window with the clinically approved fluorescence agent indocyanine green: a promising imaging technology for intraoperative diagnosis. Theranostics. 2020; 10(8):3636-3651. PMC: 7069080. DOI: 10.7150/thno.41127. View

20.

Zhang C, Shao Y, Yang S, Bi X, Wang H, Yang N . T-cell tolerance and exhaustion in the clearance of Echinococcus multilocularis: role of inoculum size in a quantitative hepatic experimental model. Sci Rep. 2017; 7(1):11153. PMC: 5593833. DOI: 10.1038/s41598-017-11703-1. View