Long-term Survival with Nivolumab Followed by Irinotecan After Total Gastrectomy in Alpha-fetoprotein-producing Gastric Cancer: a Case Report and Review of the Literature

Overview

Journal Surg Case Rep

Specialty General Surgery

Date 2023 May 7

PMID 37150760

Authors

Takayo Ota

Katsuya Sakashita

Ryugo Sawada

Kurumi Seki

Hiroyuki Maeda

Noriko Tanaka

Toshimasa Tsujinaka

Affiliations

Soon will be listed here.

Abstract

Background: Alpha-fetoprotein-producing gastric cancer (AFPGC) is a rare type of aggressive gastric cancer (GC) with a dismal prognosis. We present a patient with AFPGC who achieved long-term survival through a multidisciplinary approach.

Case Presentation: A 67-year-old man with advanced GC was referred to our hospital for systemic chemotherapy. He was diagnosed with cStage IVB AFPGC. During 2nd-line treatment, we could not control bleeding from the GC itself. After complete resection, during chemotherapy, portal venous tumor thrombi (PVTTs) and liver metastases were identified. With nivolumab followed by irinotecan, the PVTTs and liver metastases disappeared. Without immunotherapy and chemotherapy for 23 months, the patient has survived for 48 months so far with no recurrence of GC.

Conclusion: Long-term survival with AFPGC can be accomplished by using several different approaches, such as surgery, immunotherapy, and chemotherapy.

Citing Articles

Genomic landscape and potential therapeutic targets in alpha-fetoprotein-producing gastric cancer.

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Case report: Significant response of alpha-fetoprotein-producing gastric cancer from combined chemotherapy and immunotherapy.

Da X, Juan Z, Zhijun H, Zhongchuan L Front Immunol. 2024; 15:1448875.

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