An Hspa8 Variant is a Shocking Modifier of Spinal Muscular Atrophy in Mice
Overview
Affiliations
In this issue of Neuron, Kim et al. show that an Hspa8 variant modifies disease phenotypes in a mouse model of spinal muscular atrophy. Hspa8 facilitates the correct folding of proteins, enhances SNARE assembly, and influences SMN2 splicing.
Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis.
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