Immunogenetic Aspects of Intracerebral Skin Transplantation in Inbred Rats

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1979 Mar 1

PMID 371412

Citations 3

Authors

S J Geyer

T J Gill 3rd

Affiliations

Soon will be listed here.

Abstract

This study was undertaken to evaluate the ability of intracerebral skin grafts transplanted across different genetic disparities in the major histocompatibility complex (RT1) to elicit an immune response in inbred rats, as determined by histologic examination and by the ability of the grafts to sensitize the recipients to subsequent orthotopic skin grafts. The ability of intracerebral skin allografts to sensitize rats to transplantation antigens is related to the specific genetic disparity between the graft and the host: sensitization appears to occur more consistently across an A region barrier than across a B region barrier. Histologic changes of intracerebral graft rejection are more severe in rats with two intracerebral grafts than in those with one. The degree of histologic change attributable to intracerebral allograft rejection correlates with the ability of these grafts to sensitize the recipient. In certain strains intracerebral sensitization is accomplished with two grafts but not with one, indicating an antigenic dose requirement for intracerebral sensitization.

Citing Articles

Xenografting of fetal mouse hippocampal tissue to the brain of adult rats: effects of cyclosporin A treatment.

Finsen B, Poulsen P, Zimmer J Exp Brain Res. 1988; 70(1):117-33.

PMID: 3402559 DOI: 10.1007/BF00271854.

Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis.

Widner H, Brundin P Brain Res. 1988; 472(3):287-324.

PMID: 3066438 PMC: 7133672. DOI: 10.1016/0165-0173(88)90010-0.

Survival and immunogenicity of dissociated allogeneic fetal neural dopamine-rich grafts when implanted into the brains of adult mice.

Widner H, Brundin P, Bjorklund A, Moller E Exp Brain Res. 1989; 76(1):187-97.

PMID: 2753100 DOI: 10.1007/BF00253636.

References

Gibson T, Medawar P . The fate of skin homografts in man. J Anat. 1943; 77(Pt 4):299-310.4. PMC: 1252734. View

Strober S, Gowans J . THE ROLE OF LYMPHOCYTES IN THE SENSITIZATION OF RATS TO RENAL HOMOGRAFTS. J Exp Med. 1965; 122:347-60. PMC: 2138060. DOI: 10.1084/jem.122.2.347. View

LAMBERT P, Frank H . BELLMAN S, FARNSWORTH D: THE ROLE OF THE LYMPH TRUNKS IN THE RESPONSE TO ALLOGENEIC SKIN TRANSPLANTS. Transplantation. 1965; 3:62-73. DOI: 10.1097/00007890-196501000-00009. View

Billingham R, Silvers W . STUDIES ON HOMOGRAFTS OF FOETAL AND INFANT SKIN AND FURTHER OBSERVATIONS ON THE ANOMALOUS PROPERTIES OF POUCH SKIN GRAFTS IN HAMSTERS. Proc R Soc Lond B Biol Sci. 1964; 161:168-90. DOI: 10.1098/rspb.1964.0087. View

SCHEINBERG L, EDELMAN F, Levy W . IS THE BRAIN "AN IMMUNOLOGICALLY PRIVILEGED SITE"?I. STUDIES BASED ON INTRACEREBRAL TUMOR HOMOTRANSPLANTATION AND ISOTRANSPLANTATION TO SENSITIZED HOSTS. Arch Neurol. 1964; 11:248-64. DOI: 10.1001/archneur.1964.00460210026003. View

Greene H . Heterotransplantation of tumors. Ann N Y Acad Sci. 1957; 69(4):818-29. DOI: 10.1111/j.1749-6632.1957.tb49720.x. View

VOISIN G, MAUER P . Studies on the role of antibodies in the failure of homografts. Ann N Y Acad Sci. 1957; 64(5):1053-70; discussion, 1070-3. DOI: 10.1111/j.1749-6632.1957.tb52496.x. View

Mitchison N . Studies on the immunological response to foreign tumor transplants in the mouse. I. The role of lymph node cells in conferring immunity by adoptive transfer. J Exp Med. 1955; 102(2):157-77. PMC: 2136501. DOI: 10.1084/jem.102.2.157. View

Mitchison N . Passive transfer of transplantation immunity. Proc R Soc Lond B Biol Sci. 1954; 142(906):72-87. DOI: 10.1098/rspb.1954.0007. View

10.

Greene H . The transplantation of human brain tumors to the brains of laboratory animals. Cancer Res. 1953; 13(6):422-6. View

11.

GREENE H . A conception of tumor autonomy based on transplantation studies: a review. Cancer Res. 1951; 11(12):899-903. View

12.

GREENE H . The transplantation of tumors to the brains of heterologous species. Cancer Res. 1951; 11(7):529-34. View

13.

Raju S, GROGAN J . Immunologic study of the brain as a privileged site. Transplant Proc. 1977; 9(1):1187-91. View

14.

Stark O, Kunz H, Gill 3rd T . Comparison of the haplotypes of the major histocompatibility complex in the rat. III. Two difficult haplotypes: H-1h (Ag-B12) in the HW strain and Ag-B13 (H-1m) in the MNR/N strain. J Immunogenet. 1978; 5(4):261-73. DOI: 10.1111/j.1744-313x.1978.tb00654.x. View

15.

Barker C, Billingham R . Immunologically privileged sites. Adv Immunol. 1977; 25:1-54. View

16.

Albright A, Gill 3rd T, Geyer S . Immunogenetic control of brain tumor growth in rats. Cancer Res. 1977; 37(8 Pt 1):2512-21. View

17.

HASEK M, CHUTNA J, Sladecek M, Lodin Z . Immunological tolerance and tumor allografts in the brain. Nature. 1977; 268(5615):68-9. DOI: 10.1038/268068a0. View

18.

Barker C, Billingham R . The lymphatic status of hamster cheek pouch tissue in relation to its properties as a graft and as a graft site. J Exp Med. 1971; 133(3):620-39. PMC: 2138943. DOI: 10.1084/jem.133.3.620. View

19.

Lance E . A functional and morphologic study of intracranial thyroid allografts in the dog. Surg Gynecol Obstet. 1967; 125(3):529-39. View

20.

Barker C, Billingham R . Histocompatibility requirements of heart and skin grafts in rats. Transplant Proc. 1971; 3(1):172-5. View