Pharmacokinetics of Cancer Therapeutics and Energy Balance: the Role of Diet Intake, Energy Expenditure, and Body Composition

Overview

Journal J Natl Cancer Inst Monogr

Publisher Oxford University Press

Specialty Oncology

Date 2023 May 4

PMID 37139976

Authors

Sarah A Purcell

Dieuwertje E Kok

Tyler Ketterl

Miriam B Garcia

Lenat Joffe

Justin C Brown

Christina M Dieli-Conwright

Grant R Williams

Affiliations

Soon will be listed here.

Abstract

Energy balance accounts for an individual's energy intake, expenditure, and storage. Each aspect of energy balance has implications for the pharmacokinetics of cancer treatments and may impact an individual's drug exposure and subsequently its tolerance and efficacy. However, the integrated effects of diet, physical activity, and body composition on drug absorption, metabolism, distribution, and excretion are not yet fully understood. This review examines the existing literature on energy balance, specifically the role of dietary intake and nutritional status, physical activity and energy expenditure, and body composition on the pharmacokinetics of cancer therapeutics. As energy balance and pharmacokinetic factors can be influenced by age-related states of metabolism and comorbidities, this review also explores the age-related impact of body composition and physiologic changes on pharmacokinetics among pediatric and older adult populations with cancer.

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