Immune-related Mechanisms and Immunotherapy in Extragonadal Germ Cell Tumors

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 May 4

PMID 37138865

Authors

Weigang Xiu

Jiyun Pang

Yang Hu

Huashan Shi

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Extragonadal germ cell tumors (EGCTs) are relatively rare tumors, accounting for 1%-5% of all GCTs. In this review, we summarize the current research progress regarding the pathogenesis, diagnosis, and treatment of EGCTs from an immunology perspective.

Recent Findings: The histological origin of EGCTs is related to a gonadal origin, but they are located outside the gonad. They show great variation in morphology and can occur in the cranium, mediastinum, sacrococcygeal bone, and other areas. The pathogenesis of EGCTs is poorly understood, and their differential diagnosis is extensive and challenging. EGCT behavior varies greatly according to patient age, histological subtype, and clinical stage.

Summary: This review provides ideas for the future application of immunology in the fight against such diseases, which is a hot topic currently.

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