The Role of Delta Superinfection in Acute Exacerbations of Chronic Type B Hepatitis

Overview

Journal Liver

Specialty Gastroenterology

Date 1986 Feb 1

PMID 3713452

Citations 4

Authors

C M Chu

P Farci

Y F Liaw

A Balestrieri

H C Thomas

Affiliations

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Abstract

Serum specimens collected from patients with chronic type B hepatitis during their acute exacerbations were studied with radioimmunoassay for serological markers of delta (delta) agent infection. Serum delta antigen was negative in all 56 hepatitis B e antigen (HBeAg)-positive and 25 anti-HBe-positive acute exacerbations. Two (3.6%) HBeAg-positive and five (20%) anti-HBe-positive acute exacerbations were found to be positive for both IgG anti-delta and IgM anti-delta. The incidence in anti-HBe-positive patients was significantly higher than in HBeAg-positive patients. These results indicated that some of the acute exacerbations, particularly in anti-HBe-positive phase, could be attributed to delta-superinfection. However, acute exacerbations preceding HBeAg/anti-HBe seroconversion were not associated with delta-superinfection.

Citing Articles

The aetiology of acute hepatitis in Taiwan: acute hepatitis superimposed on HBsAg carrier state as the main aetiology of acute hepatitis in areas with high HBsAg carrier rate.

Chu C, Sheen I, Liaw Y Infection. 1988; 16(4):233-7.

PMID: 3141291 DOI: 10.1007/BF01650760.

Prevalence and significance of intrahepatic hepatitis delta virus antigen expression in HBeAg-negative patients with chronic type-B hepatitis in Taiwan.

Chu C, Shyu W, Liaw Y Dig Dis Sci. 1989; 34(12):1911-5.

PMID: 2689112 DOI: 10.1007/BF01536711.

Immunohistochemical research on HDV infection in Chinese patients with chronic liver disease.

Zhang Y, Hao L, Rizzetto M, Bonino F, Verme G J Tongji Med Univ. 1989; 9(1):5-7.

PMID: 2547981 DOI: 10.1007/BF02933735.

Etiology of acute exacerbation in patients with severe chronic active hepatitis by in situ HBVDNA hybridization technique.

Zhang Y, Wang Y, Sheng H, Li L, Hao L, Zhang Y J Tongji Med Univ. 1990; 10(1):5-9.

PMID: 2348490 DOI: 10.1007/BF02909113.