Smoking Affects the Predictive Roles of Antioxidant Enzymes in the Clinical Response to Risperidone in Schizophrenia: A Large-scale Cohort Study

Overview

Journal Curr Neuropharmacol

Publisher Bentham Science Publishers

Date 2023 May 3

PMID 37132112

Authors

Meihong Xiu

Xiuli Song

Hanlun Yang

Xingjuan Huang

Fengchun Wu

Xiangyang Zhang

Affiliations

Soon will be listed here.

Abstract

Objectives: There is overwhelming evidence of the relationship between smoking and schizophrenia (SZ). Tobacco smoke is considered to ameliorate the symptoms and reduce the side effects of antipsychotics in SZ patients. However, the underlying biological mechanism by which tobacco smoke improves symptoms in SZ remains unclear. This study was designed to examine the effects of tobacco smoke on antioxidant enzyme activities and psychiatric symptoms after receiving 12-week risperidone monotherapy.

Methods: Two hundred and fifteen antipsychotic-naïve first-episode (ANFE) patients were recruited and treated with risperidone for 3 months. The severity of the patient's symptoms was assessed by the Positive and Negative Syndrome Scale (PANSS) at baseline and at post-treatment. Plasma SOD, GSH-Px, and CAT activities were determined at baseline and follow-up.

Results: Relative to nonsmoking patients with ANFE SZ, patients who smoked had higher baseline CAT activity. In addition, among non-smokers with SZ, baseline GSH-Px was associated with clinical symptom improvement, while baseline CAT was associated with positive symptom improvement in smokers with SZ.

Conclusion: Our findings demonstrate that smoking affects the predictive role of baseline SOD, GSHPx, and CAT activities on clinical symptom improvement in patients with SZ.

Citing Articles

Variations to plasma HO levels and TAC in chronical medicated and treatment-resistant male schizophrenia patients: Correlations with psychopathology.

Yang H, Sun W, Yang M, Li J, Zhang J, Zhang X Schizophrenia (Heidelb). 2024; 10(1):45.

PMID: 38605069 PMC: 11009317. DOI: 10.1038/s41537-024-00468-y.

References

Ho S, Chan-Yeung M, Chow K, Ip M, Mak J . Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender and smoking. Respirology. 2005; 10(3):305-9. DOI: 10.1111/j.1440-1843.2005.00702.x. View

Brigelius-Flohe R . Tissue-specific functions of individual glutathione peroxidases. Free Radic Biol Med. 1999; 27(9-10):951-65. DOI: 10.1016/s0891-5849(99)00173-2. View

Glassman A . Cigarette smoking: implications for psychiatric illness. Am J Psychiatry. 1993; 150(4):546-53. DOI: 10.1176/ajp.150.4.546. View

Cecerska-Heryc E, Polikowska A, Serwin N, Roszak M, Grygorcewicz B, Heryc R . Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review. Neurochem Int. 2021; 153:105269. DOI: 10.1016/j.neuint.2021.105269. View

Changeux J . Nicotine addiction and nicotinic receptors: lessons from genetically modified mice. Nat Rev Neurosci. 2010; 11(6):389-401. DOI: 10.1038/nrn2849. View

Sagud M, Vuksan-Cusa B, Jaksic N, Mihaljevic-Peles A, Zivkovic M, Vlatkovic S . Nicotine dependence in Croatian male inpatients with schizophrenia. BMC Psychiatry. 2018; 18(1):18. PMC: 5778660. DOI: 10.1186/s12888-018-1606-1. View

Montuschi P, Collins J, Ciabattoni G, Lazzeri N, Corradi M, Kharitonov S . Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med. 2000; 162(3 Pt 1):1175-7. DOI: 10.1164/ajrccm.162.3.2001063. View

Winterer G . Why do patients with schizophrenia smoke?. Curr Opin Psychiatry. 2010; 23(2):112-9. DOI: 10.1097/YCO.0b013e3283366643. View

Kay S, Fiszbein A, Opler L . The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987; 13(2):261-76. DOI: 10.1093/schbul/13.2.261. View

10.

Fang Y, Wang W, Zhu C, Lin G, Cheng Y, Zou J . Use of tobacco in schizophrenia: A double-edged sword. Brain Behav. 2019; 9(11):e01433. PMC: 6851808. DOI: 10.1002/brb3.1433. View

11.

Bolzan A, Bianchi M, Bianchi N . Superoxide dismutase, catalase and glutathione peroxidase activities in human blood: influence of sex, age and cigarette smoking. Clin Biochem. 1997; 30(6):449-54. DOI: 10.1016/s0009-9120(97)00047-7. View

12.

Dalack G, Meador-Woodruff J . Smoking, smoking withdrawal and schizophrenia: case reports and a review of the literature. Schizophr Res. 1996; 22(2):133-41. DOI: 10.1016/s0920-9964(96)80441-5. View

13.

Chen N, Liu H, Yao J, Chen S, Xiu M, Wu F . Smoke, GPx activity and symptoms improvement in patients with drug-naive first-episode schizophrenia: A large-scale 12-week follow-up study. Asian J Psychiatr. 2022; 77:103267. DOI: 10.1016/j.ajp.2022.103267. View

14.

Schoretsanitis G, Haen E, Stegmann B, Hiemke C, Grunder G, Paulzen M . Effect of smoking on risperidone pharmacokinetics - A multifactorial approach to better predict the influence on drug metabolism. Schizophr Res. 2016; 185:51-57. DOI: 10.1016/j.schres.2016.12.016. View

15.

Rangasamy T, Cho C, Thimmulappa R, Zhen L, Srisuma S, Kensler T . Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest. 2004; 114(9):1248-59. PMC: 524225. DOI: 10.1172/JCI21146. View

16.

Sidle E, Casselman R, Smith G . Effect of cigarette smoke on placental antioxidant enzyme expression. Am J Physiol Regul Integr Comp Physiol. 2007; 293(2):R754-8. DOI: 10.1152/ajpregu.00505.2006. View

17.

Guan Z, Yu W, Nordberg A . Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells. Neurochem Int. 2003; 43(3):243-9. DOI: 10.1016/s0197-0186(03)00009-3. View

18.

Stolz P, Wehring H, Liu F, Love R, Ellis M, DiPaula B . Effects of Cigarette Smoking and Clozapine Treatment on 20-Year All-Cause & Cardiovascular Mortality in Schizophrenia. Psychiatr Q. 2019; 90(2):351-359. PMC: 6525042. DOI: 10.1007/s11126-018-9621-4. View

19.

MacNee W, Rahman I . Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999; 160(5 Pt 2):S58-65. DOI: 10.1164/ajrccm.160.supplement_1.15. View

20.

Correll C, Schooler N . Negative Symptoms in Schizophrenia: A Review and Clinical Guide for Recognition, Assessment, and Treatment. Neuropsychiatr Dis Treat. 2020; 16:519-534. PMC: 7041437. DOI: 10.2147/NDT.S225643. View