Acute Adrenal Insufficiency Caused by Mental Stress in a Patient With Adrenocorticotropic Hormone Deficiency

In patients with chronic adrenal insufficiency, physical stress increases the requirement for glucocorticoid therapy. Although mental stress may cause acute adrenal insufficiency, it is debatable how patients should be treated when experiencing mental stress. Here, we report the case of a female patient with septo-optic dysplasia who had been treated for adrenocorticotropic hormone deficiency since infancy. After her grandfather died when she was 17 years old, she complained of nausea and stomach pain. Her symptoms failed to improve despite treatment with stress doses of oral hydrocortisone and self-administered glucagon injection. Her general condition improved after she began receiving continuous hydrocortisone and glucose infusions. Glucocorticoid stress doses should be given early if a patient is likely to experience mental stress.