Investigating the Shape and Strength of the Relationship Between Maternal Weight Gain and Gestational Age at Delivery in Twin and Singleton Pregnancies

Overview

Journal Am J Epidemiol

Publisher Oxford University Press

Specialty Public Health

Date 2023 May 2

PMID 37127908

Authors

Michelle C Dimitris

Jennifer A Hutcheon

Robert W Platt

Michal Abrahamowicz

Marie-Eve Beauchamp

Katherine P Himes

Lisa M Bodnar

Jay S Kaufman

Affiliations

Soon will be listed here.

Abstract

Both inadequate and excessive maternal weight gain are correlated with preterm delivery in singleton pregnancies, yet this relationship has not been adequately studied in twins. We investigated the relationship between time-varying maternal weight gain and gestational age at delivery in twin pregnancies and compared it with that in singletons delivered in the same study population. We used serial weight measurements abstracted from charts for twin and singleton pregnancies delivered during 1998-2013 in Pittsburgh, Pennsylvania. Our exposure was time-varying weight gain z score, calculated using gestational age-standardized and prepregnancy body mass index-stratified twin- and singleton-specific charts, and our outcome was gestational age at delivery. Our analyses used a flexible extension of the Cox proportional hazards model that allowed for nonlinear and time-dependent effects. We found a U-shaped relationship between weight gain z score and gestational age at delivery among twin pregnancies (lowest hazard of delivery observed at z score = 1.2), which we attributed to increased hazard of early preterm spontaneous delivery among pregnancies with low weight gain and increased hazard of late preterm delivery without labor among pregnancies with high weight gain. Our findings may be useful for updating provisional guidelines for maternal weight gain in twin pregnancies.

Citing Articles

Effect of gestational weight gain on adverse birth outcomes in twin pregnancies: a prospective cohort study in Chinese women.

Zhao R, Zhang A, Wang Y, Chai Y, Du F, Xu Q BMC Pregnancy Childbirth. 2025; 25(1):169.

PMID: 39962413 PMC: 11834644. DOI: 10.1186/s12884-025-07234-7.

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